Department of Pharmaceutics and Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, PR China.
Cancer Institute, Affiliated Hospital of Qingdao University, Qingdao 266061, PR China.
Carbohydr Polym. 2020 Feb 15;230:115573. doi: 10.1016/j.carbpol.2019.115573. Epub 2019 Nov 7.
Many kinds of multi-drug-resistant microorganisms have appeared. Moreover, monotherapy is increasingly no longer adequate for many complicated bacterial infections. Therefore, development of efficient combination antibacterial agent is becoming crucial. Herein, we present a hybrid antibacterial agent with enhanced antibacterial activity and high aqueous dissolubility based on silver nanoparticles and curcumin. The silver nanoparticles were firstly synthesized using oxidized amylose as an environmentally friendly reducing agent and stabilizer. Then, curcumin was added into the above mixture to get the hybrid antibacterial agent. The hybrid antibacterial agent presented high dissolubility in aqueous solution and enhanced antibacterial activity. In addition, the hybrid antibacterial agent presented good antioxidant activity and cell compatibility. Overall, the developed hybrid antibacterial agent has a potential to combat multiple bacteria-induced infections of wound surfaces.
已经出现了许多种耐药微生物。此外，对于许多复杂的细菌感染，单药治疗越来越不够用。因此，开发高效的组合抗菌剂变得至关重要。在此，我们提出了一种基于银纳米粒子和姜黄素的具有增强抗菌活性和高水溶性的混合抗菌剂。首先使用氧化淀粉作为环保型还原剂和稳定剂合成银纳米粒子。然后，将姜黄素加入到上述混合物中得到混合抗菌剂。该混合抗菌剂在水溶液中具有高溶解性和增强的抗菌活性。此外，该混合抗菌剂还具有良好的抗氧化活性和细胞相容性。总的来说，所开发的混合抗菌剂具有治疗创面多种细菌感染的潜力。
