National Institute of Laser Enhanced Sciences (NILE), Cairo University, Giza 12613, Egypt.
Egypt Nanotechnology Center (EGNC), Cairo University, El-Sheikh Zayed 12588, Egypt.
Future Med Chem. 2018 Nov;10(22):2577-2588. doi: 10.4155/fmc-2018-0152. Epub 2018 Dec 11.
There is an urgent need to develop alternative antimicrobial agents and, one of which is via the use of nanotechnology. Green synthetic routes are recently being replaced for nanoparticles preparation. Methods results: Silver-curcumin nanoconjugates (Ag-CurNCs) were prepared in an eco-friendly method. The prepared nanomaterials were characterized and the photostability was studied under the influence of UV irradiation. Results showed that, the conjugation between curcumin and silver in the nanoform improve the photostability of curcumin. Cytotoxicity was studied on different skin cell lines, and antibacterial activity was investigated against Escherichia coli. Results revealed the antibacterial activity of the prepared nanoconjugates (Ag-CurNCs) with minimal toxicity to skin cells.
Silver nanoparticles improve the photostability and antibacterial activity of curcumin, while curcumin helps in preparing biocompatible silver nanoparticles.
迫切需要开发替代抗菌剂，其中之一是利用纳米技术。绿色合成路线最近正在被取代，用于制备纳米粒子。方法结果：银-姜黄素纳米复合物（Ag-CurNCs）采用环保方法制备。对制备的纳米材料进行了表征，并研究了在紫外光照射下的光稳定性。结果表明，纳米形式下姜黄素与银的结合提高了姜黄素的光稳定性。在不同的皮肤细胞系上研究了细胞毒性，并且研究了其对大肠杆菌的抗菌活性。结果表明，所制备的纳米复合物（Ag-CurNCs）具有抗菌活性，同时对皮肤细胞的毒性最小。
银纳米粒子提高了姜黄素的光稳定性和抗菌活性，而姜黄素有助于制备生物相容性的银纳米粒子。
