Shafiee Gita, Heshmat Ramin, Ostovar Afshin, Nabipour Iraj, Larijani Bagher
1Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, NO 10, Jalale-Al-Ahmad Ave, Chamran Highway, Tehran, Iran.
2Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
J Diabetes Metab Disord. 2019 Nov 15;18(2):665-674. doi: 10.1007/s40200-019-00452-9. eCollection 2019 Dec.
Sarcopenia is a geriatric disease with adverse clinical outcomes, high rate of mortality and a major challenge to healthy elderly. This study aimed to undertake a survey to identify gaps and highlight strengths in sarcopenia research in order to progress research in this area for the next years in Iran.
This study included all studies published from the beginning until the first of 2019 in national and international journals by Iranian authors conducted in the field of sarcopenia. The databases including MEDLINE (via PubMed), Web of Science and SCOPUS were used as the sources of information. All relevant available academic studies, including review articles, original articles, case reports, conference abstracts, and letters were included in the analysis.
A total of 48 articles obtained and then categorized into six groups. These groups were; about Pathophysiology, Epidemiology of sarcopenia, Screening of sarcopenia, Nutrition, Physical activity and Association of Sarcopenia and Other Diseases that briefly findings of each study had been described. These findings showed that the prevalence of sarcopenia was 16.5% to 32.5%, using different definitions. A study developed and validated a screening model for identifying people with sarcopenia. Lifestyle changes such as diet can be appropriate strategies for the prevention of sarcopenia and also, physical activity is considered to be one of the few effective strategies to improve sarcopenia and prevent its outcomes, especially if in combination with appropriate nutritional supplementation. Sarcopenia is associated with adverse outcomes and other serious areas such as metabolic disorders, cancers, cardiovascular diseases, nephrology, gastroenterology, psychiatry, other geriatric diseases (such as osteoporosis, etc) and death. Some studies about these areas have been done in Iran.
By this study, we found that studies on sarcopenia, the gaps of sarcopenia research in Iran, and highlighted the research priorities for future works. The outcome of the present research is to ultimately improve the health, quality of life and well-being of sarcopenic people.
肌肉减少症是一种具有不良临床结局、高死亡率的老年疾病，对健康老年人构成重大挑战。本研究旨在进行一项调查，以找出肌肉减少症研究中的差距并突出优势，从而推动伊朗未来几年该领域的研究进展。
本研究纳入了伊朗作者在2019年1月之前在国内外期刊上发表的所有关于肌肉减少症领域的研究。MEDLINE（通过PubMed）、科学网和Scopus等数据库被用作信息来源。分析纳入了所有相关的现有学术研究，包括综述文章、原创文章、病例报告、会议摘要和信函。
共获得48篇文章，然后分为六组。这些组分别是：关于肌肉减少症的病理生理学、流行病学、筛查、营养、体育活动以及肌肉减少症与其他疾病的关联，每项研究的简要结果都已描述。这些结果表明，使用不同定义，肌肉减少症的患病率为16.5%至32.5%。一项研究开发并验证了一种用于识别肌肉减少症患者的筛查模型。饮食等生活方式的改变可能是预防肌肉减少症的合适策略，此外，体育活动被认为是改善肌肉减少症并预防其后果的少数有效策略之一，特别是如果与适当的营养补充相结合。肌肉减少症与不良结局以及其他严重领域相关，如代谢紊乱、癌症、心血管疾病、肾脏病学、胃肠病学、精神病学、其他老年疾病（如骨质疏松症等）和死亡。伊朗已经开展了一些关于这些领域的研究。
通过本研究，我们发现了关于肌肉减少症的研究、伊朗肌肉减少症研究中的差距，并突出了未来工作的研究重点。本研究的结果最终是为了改善肌肉减少症患者的健康、生活质量和幸福感。
