糖尿病患者肌肉减少症的风险评估与治疗选择综述
A comprehensive review on the risks assessment and treatment options for Sarcopenia in people with diabetes.
作者信息
Johri Nishant, Vengat Maheshwari, Kumar Deepanshu, Nagar Priya, John Davis, Dutta Shubham, Mittal Piyush
机构信息
Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, Moradabad, Uttar Pradesh India.
Department of Oncology, University of Chester, Chester, UK.
出版信息
J Diabetes Metab Disord. 2023 Jul 30;22(2):995-1010. doi: 10.1007/s40200-023-01262-w. eCollection 2023 Dec.
OBJECTIVES
This comprehensive review aims to examine the reciprocal interplay between Type 2 diabetes mellitus (T2DM) and sarcopenia, identify prevailing research gaps, and discuss therapeutic approaches and measures to enhance healthcare practices within hospital settings.
METHODS
A thorough literature review was conducted to gather relevant studies and articles on the relationship between T2DM and sarcopenia. Various databases were searched, including Google Scholar, PubMed, Scopus, and Science Direct databases. The search terms included T2DM, sarcopenia, inflammation, insulin resistance, advanced glycation end products, oxidative stress, muscle dimensions, muscle strength, muscle performance, aging, nutrition, hormone levels, and physical activity. The collected articles were critically analysed to extract key findings and identify gaps in current research.
RESULTS
The prevalence and incidence of metabolic and musculoskeletal disorders, notably T2DM and sarcopenia, have surged in recent years. T2DM is marked by inflammation, insulin resistance, accumulation of advanced glycation end products, and oxidative stress, while sarcopenia involves a progressive decline in skeletal muscle mass and function. The review underscores the age-related correlation between sarcopenia and adverse outcomes like fractures, falls, and mortality. Research gaps regarding optimal nutritional interventions for individuals with T2DM and sarcopenia are identified, emphasizing the necessity for further investigation in this area.
CONCLUSIONS
The reciprocal interplay between T2DM and sarcopenia holds significant importance. Further research is warranted to address knowledge gaps, particularly in utilizing precise measurement tools during clinical trials. Lifestyle modifications appear beneficial for individuals with T2DM and sarcopenia. Additionally, practical nutritional interventions require investigation to optimize healthcare practices in hospital settings.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s40200-023-01262-w.
目的
本综述旨在探讨2型糖尿病（T2DM）与肌肉减少症之间的相互作用，找出当前主要的研究空白，并讨论在医院环境中加强医疗实践的治疗方法和措施。
方法
进行了全面的文献综述，以收集有关T2DM与肌肉减少症关系的相关研究和文章。搜索了各种数据库，包括谷歌学术、PubMed、Scopus和科学Direct数据库。搜索词包括T2DM、肌肉减少症、炎症、胰岛素抵抗、晚期糖基化终产物、氧化应激、肌肉维度、肌肉力量、肌肉性能、衰老、营养、激素水平和身体活动。对收集到的文章进行了批判性分析，以提取关键发现并确定当前研究中的空白。
结果
近年来，代谢和肌肉骨骼疾病（尤其是T2DM和肌肉减少症）的患病率和发病率大幅上升。T2DM的特征是炎症、胰岛素抵抗、晚期糖基化终产物的积累和氧化应激，而肌肉减少症则涉及骨骼肌质量和功能的逐渐下降。该综述强调了肌肉减少症与骨折、跌倒和死亡率等不良后果之间的年龄相关性。确定了关于T2DM和肌肉减少症患者最佳营养干预措施的研究空白，强调了在该领域进一步研究的必要性。
结论
T2DM与肌肉减少症之间的相互作用具有重要意义。有必要进行进一步研究以填补知识空白，特别是在临床试验中使用精确测量工具方面。生活方式的改变对T2DM和肌肉减少症患者似乎有益。此外，需要对实际的营养干预措施进行研究，以优化医院环境中的医疗实践。
补充信息
在线版本包含可在10.1007/s40200-023-01262-w上获取的补充材料。
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