一种用于小鼠模型老年性聋的中药复方（健耳）：减少细胞凋亡并保护耳蜗感觉神经细胞及听力。
A traditional Chinese medicine compound (Jian Er) for presbycusis in a mouse model: Reduction of apoptosis and protection of cochlear sensorineural cells and hearing.
作者信息
Xuan Yi, Ding Dalian, Xuan Weijun, Huang Liyi, Tang Junbo, Wei Yulong, Chen Sizhong, Hamblin Michael R
机构信息
School of Engineering, Tufts University, Medford, MA, USA.
Center for Hearing Deafness, the State University of New York at Buffalo, Buffalo, NY, USA.
出版信息
Int J Herb Med. 2018 Nov-Dec;6(6):127-135.
Abstract
Age-related hearing loss (AHL) or presbycusis is steadily increasing due to the overall aging of the Chinese population. Traditional Chinese medicine (TCM) has long been used to prevent and treat deafness, but its effectiveness and mechanism of action are still uncertain. The present study tested a TCM preparation called "Jian Er" in a mouse model of prebycusis.
摘要
由于中国人口的整体老龄化，年龄相关性听力损失（AHL）或老年性聋正在稳步增加。长期以来，中医一直被用于预防和治疗耳聋，但其有效性和作用机制仍不确定。本研究在老年性聋小鼠模型中测试了一种名为“健耳”的中药制剂。
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本文引用的文献
1
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Biores Open Access. 2015 Feb 1;4(1):146-59. doi: 10.1089/biores.2014.0058. eCollection 2015.
2
Ouabain-induced apoptosis in cochlear hair cells and spiral ganglion neurons in vitro.哇巴因诱导的体外耳蜗毛细胞和螺旋神经节神经元凋亡。
Biomed Res Int. 2013;2013:628064. doi: 10.1155/2013/628064. Epub 2013 Oct 22.
3
Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures.外源性 NAD+ 通过减少耳蜗器官型培养物中 caspase-3 介导的凋亡，预防甲氟喹诱导的神经轴突和毛细胞变性。
PLoS One. 2013 Nov 6;8(11):e79817. doi: 10.1371/journal.pone.0079817. eCollection 2013.
4
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5
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