Eckert R, von Baehr R
Institut für Medizinische Immunologie, Bereichs Medizin (Charité) Humboldt-Universität zu Berlin.
Allerg Immunol (Leipz). 1988;34(2):67-71.
Using three models of immune reactions - the DTH-reaction, the GvH-reaction, and the modulation of immune reactions by histamine - we show that the strain-dependent variability between different inbred strains may exist not only on the quantitative but also on the qualitative level. For many problems it seems necessary to test the suitability of different mouse strains to avoid errors.
利用三种免疫反应模型——迟发型超敏反应(DTH反应)、移植物抗宿主反应(GvH反应)以及组胺对免疫反应的调节作用——我们发现,不同近交系之间因品系而异的变异性不仅可能存在于数量层面,还可能存在于质量层面。对于许多问题而言,似乎有必要测试不同小鼠品系的适用性,以避免出现错误。