Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India.
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India.
Reprod Biol. 2020 Mar;20(1):3-8. doi: 10.1016/j.repbio.2019.11.005. Epub 2019 Dec 28.
The toxicity of metals is a known phenomenon. Nickel toxicity is very common since nickel is used extensively both industrially and in items of personal use such as utensils and jewellery. Here we discuss human exposure to nickel and its toxicity in the light of the available scientific evidence to understand its underlying pathophysiology. The ability of Ni to get oxidized to Ni renders it's potential of generating reactive oxygen species (ROS) in the system leading to oxidative stress. Carcinogenesis, apoptosis induction, contact dermatitis, epigenetic changes, and alteration in gene regulation are a result of overexposure of nickel. Our focus is on how nickel affects the male reproductive physiology. Nickel primarily drives ROS mediated perturbations in the male reproductive system. It influences zinc metabolism, which is critical for sperm stability and affects the structure of DNA binding proteins, including protamines, thereby affecting sperm function.
金属的毒性是一种已知的现象。镍毒性非常常见，因为镍在工业和个人用品（如餐具和珠宝）中广泛使用。在这里，我们根据现有科学证据讨论人类接触镍及其毒性，以了解其潜在的病理生理学。镍能够被氧化成 Ni，这使得它有潜力在系统中产生活性氧物种 (ROS)，从而导致氧化应激。致癌作用、细胞凋亡诱导、接触性皮炎、表观遗传改变和基因调控改变都是镍过度暴露的结果。我们关注的是镍如何影响男性生殖生理学。镍主要通过 ROS 介导的干扰来影响男性生殖系统。它影响锌代谢，这对精子稳定性至关重要，并影响 DNA 结合蛋白的结构，包括鱼精蛋白，从而影响精子功能。
