Trauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Beijing 100048, People's Republic of China.
Department of Burn Surgery, Changhai Hospital, the Naval Medical University, Shanghai 200433, People's Republic of China.
Int J Biol Sci. 2020 Jan 1;16(1):27-37. doi: 10.7150/ijbs.37496. eCollection 2020.
Sepsis is an intractable disorder, which is associated with high risk of organ dysfunction and even death, while its pathogenesis remains largely unclear. Our study aims to study the research trend on sepsis and host immune response, and compare the contribution of publications from different countries, institutions, journals and authors. We extracted all relevant publications with regard to sepsis and immune response during 1999-2019 from Web of Science. GraphPad Prism 6, and VOSviewer software were used to collect and analyze the publication trend in related field. We identified a total of 1225 publications with citation frequency of 40511 times up to March 30, 2019. The United States accounted for the largest number of publications (36.3%), 51.9% of total citations as well as the highest H-index (72). The sum of publications from China ranked the second, while the overall citations (1935) and H-index (22) ranked the eighth and the seventh, respectively. Journal of had published most papers related to the topic on sepsis and immune response. Ayala A SA, has published the most papers in this field (31), while Hotchkiss RS presented with the most citation frequency (3532). The keyword "regulatory T cell" appeared most recently with an average appearing years of 2014.0. The "immunosuppression related research" seemed to be the hotspot in relevant scope. The United States made the most outstanding contribution within this important field. There is a mismatch between the quantity and quality of publications from China. Latest progress can be tracked in journal of . Immunosuppression related researches may be hotspots in the near future.
脓毒症是一种棘手的疾病，与器官功能障碍甚至死亡的高风险相关，但其发病机制在很大程度上仍不清楚。本研究旨在研究脓毒症和宿主免疫反应的研究趋势，并比较来自不同国家、机构、期刊和作者的出版物的贡献。我们从 Web of Science 中提取了 1999 年至 2019 年间与脓毒症和免疫反应相关的所有相关出版物。GraphPad Prism 6 和 VOSviewer 软件用于收集和分析相关领域的出版物趋势。我们共确定了 1225 篇出版物，截至 2019 年 3 月 30 日，引用频次为 40511 次。美国发表的论文数量最多（36.3%），总引用量（51.9%）和最高 H 指数（72）最高。中国的出版物总数排名第二，而总引文数（1935）和 H 指数（22）分别排名第八和第七。发表脓毒症和免疫反应相关主题论文最多的期刊是。在这个领域发表论文最多的是（31 篇），而 Hotchkiss RS 的引用频次最高（3532 次）。“调节性 T 细胞”一词出现的时间最晚，平均出现在 2014.0 年。“免疫抑制相关研究”似乎是相关领域的热点。美国在这一重要领域做出了最杰出的贡献。中国发表的论文数量和质量之间存在不匹配。最新进展可以在杂志上跟踪。免疫抑制相关研究可能是未来的热点。
