Department of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research, Seoul National University, Seoul, South Korea.
Adv Exp Med Biol. 2020;1232:271-276. doi: 10.1007/978-3-030-34461-0_34.
Adaptation to hypoxia is essential for regulating the survival and functions of hypoxic cells; it is mainly mediated by the hypoxia-inducible factor 1 (HIF1). The alpha subunit of HIF1 (HIF1α) is a well-known regulatory component of HIF1, which is tightly controlled by various types of HIF1α-regulating processes. Previous research has shown that microtubule-regulated HIF1α nuclear translocation is a key factor for HIF1 activation under hypoxia. In this review, we summarize experimental reports on the role of microtubule-associated factors, such as microtubule, dynein, and dynein adaptor protein, in nuclear translocation of HIF1α. Based upon scientific evidence, we propose a bicaudal D homolog (BICD) as a novel HIF1α translocation regulating factor. A deeper understanding of the mechanism of the action of regulatory factors in controlling HIF1α nuclear translocation will provide novel insights into cell biology under hypoxia.
缺氧适应对于调节缺氧细胞的存活和功能至关重要；它主要由缺氧诱导因子 1（HIF1）介导。HIF1 的α亚基（HIF1α）是 HIF1 的一个众所周知的调节成分，其受到各种类型的 HIF1α 调节过程的严格控制。先前的研究表明，微管调节的 HIF1α 核易位是缺氧下 HIF1 激活的关键因素。在这篇综述中，我们总结了关于微管相关因子（如微管、动力蛋白和动力蛋白衔接蛋白）在 HIF1α核易位中的作用的实验报告。基于科学证据，我们提出了 bicaudal D 同源物（BICD）作为一种新型的 HIF1α 易位调节因子。更深入地了解调节因子在控制 HIF1α 核易位中的作用机制将为缺氧下的细胞生物学提供新的见解。
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