Lee Hyun Jik, Jung Young Hyun, Choi Gee Euhn, Kim Jun Sung, Chae Chang Woo, Han Ho Jae
Department of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research, Seoul National Universit.
Int J Stem Cells. 2019 Mar 30;12(1):8-20. doi: 10.15283/ijsc18109.
Hypoxia-inducible factor 1 (HIF1) is a master transcription factor that induces the transcription of genes involved in the metabolism and behavior of stem cells. HIF1-mediated adaptation to hypoxia is required to maintain the pluripotency and survival of stem cells under hypoxic conditions. HIF1 activity is well known to be tightly controlled by the alpha subunit of HIF1 (HIF1). Understanding the regulatory mechanisms that control HIF1 activity in stem cells will provide novel insights into stem cell biology under hypoxia. Recent research has unraveled the mechanistic details of HIF1 regulating processes, suggesting new strategies for regulating stem cells. This review summarizes recent experimental studies on the role of several regulatory factors (including calcium, 2-oxoglutarate-dependent dioxygenase, microtubule network, importin, and coactivators) in regulating HIF1 activity in stem cells.
缺氧诱导因子1（HIF1）是一种主要的转录因子，可诱导参与干细胞代谢和行为的基因转录。在缺氧条件下，HIF1介导的对缺氧的适应性是维持干细胞多能性和存活所必需的。众所周知，HIF1的活性受到HIF1α亚基（HIF1α）的严格控制。了解控制干细胞中HIF1活性的调控机制将为缺氧条件下的干细胞生物学提供新的见解。最近的研究揭示了HIF1调控过程的机制细节，为调控干细胞提出了新策略。本综述总结了近期关于几种调控因子（包括钙、2-氧代戊二酸依赖性双加氧酶、微管网络、输入蛋白和共激活因子）在调控干细胞中HIF1活性方面作用的实验研究。
