• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

血容量和体重指数对血液神经丝轻链水平的混杂影响。

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels.

机构信息

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Centre for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.

出版信息

Ann Clin Transl Neurol. 2020 Jan;7(1):139-143. doi: 10.1002/acn3.50972. Epub 2020 Jan 1.

DOI:10.1002/acn3.50972
PMID:31893563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6952306/
Abstract

Blood Neurofilament light chain (NfL) has been suggested as a promising biomarker in several neurological conditions. Since blood NfL is the consequence of leaked NfL from the cerebrospinal fluid, differences in individuals' Body Mass Index (BMI) or blood volume (BV) might affect its correlation to other biomarkers and disease outcomes. Here, we investigated the correlation between plasma NfL, BMI, and BV in 662 controls and 2,586 multiple sclerosis cases. We found a significant negative correlation between plasma NfL, BMI/BV in both groups. Our results highlight the potential confounding effect of BMI/BV on associations between blood NfL and disease outcomes.

摘要

血液神经丝轻链（NfL）已被认为是几种神经疾病有前途的生物标志物。由于血液 NfL 是脑脊液中漏出的 NfL 的结果，个体的体重指数（BMI）或血容量（BV）的差异可能会影响其与其他生物标志物和疾病结果的相关性。在这里，我们研究了 662 名对照和 2586 名多发性硬化症患者的血浆 NfL、BMI 和 BV 之间的相关性。我们发现两组的血浆 NfL 与 BMI/BV 呈显著负相关。我们的研究结果强调了 BMI/BV 对血液 NfL 与疾病结果之间关联的潜在混杂影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6d8/6952306/2ee55614ad75/ACN3-7-139-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6d8/6952306/1b6d15e5165b/ACN3-7-139-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6d8/6952306/2ee55614ad75/ACN3-7-139-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6d8/6952306/1b6d15e5165b/ACN3-7-139-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6d8/6952306/2ee55614ad75/ACN3-7-139-g002.jpg

相似文献

1
Confounding effect of blood volume and body mass index on blood neurofilament light chain levels.血容量和体重指数对血液神经丝轻链水平的混杂影响。
Ann Clin Transl Neurol. 2020 Jan;7(1):139-143. doi: 10.1002/acn3.50972. Epub 2020 Jan 1.
2
Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis.多发性硬化症随访期间的神经丝水平、疾病活动和脑容量。
J Neuroinflammation. 2018 Jul 18;15(1):209. doi: 10.1186/s12974-018-1249-7.
3
The relationship between ANT1 and NFL with autophagy and mitophagy markers in patients with multiple sclerosis.多发性硬化症患者自噬和噬线粒体标志与 ANT1 和 NFL 的关系。
J Clin Neurosci. 2020 Aug;78:307-312. doi: 10.1016/j.jocn.2020.04.122. Epub 2020 May 4.
4
Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod.多发性硬化症患者从注射治疗改为芬戈莫德后血浆神经丝轻链水平。
Mult Scler. 2018 Jul;24(8):1046-1054. doi: 10.1177/1352458517715132. Epub 2017 Jun 19.
5
Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa.三种分析平台用于定量血液样本中神经丝轻链的比较：酶联免疫吸附测定（ELISA）、电化学发光免疫测定和单分子阵列检测技术（Simoa）
Clin Chem Lab Med. 2016 Oct 1;54(10):1655-61. doi: 10.1515/cclm-2015-1195.
6
Value contribution of blood-based neurofilament light chain as a biomarker in multiple sclerosis using multi-criteria decision analysis.基于血液神经丝轻链的价值贡献作为多发性硬化症的生物标志物的多准则决策分析。
Front Public Health. 2024 Apr 22;12:1397845. doi: 10.3389/fpubh.2024.1397845. eCollection 2024.
7
Neurofilament light chain in the assessment of patients with multiple sclerosis.神经丝轻链在多发性硬化症患者评估中的应用
Arq Neuropsiquiatr. 2019 Jul 15;77(6):436-441. doi: 10.1590/0004-282X20190060.
8
Serum and cerebrospinal fluid light neurofilaments and antibodies against them in clinically isolated syndrome and multiple sclerosis.血清和脑脊液中的神经丝轻链及针对它们的抗体在临床孤立综合征和多发性硬化中的研究。
J Neuroimmunol. 2013 Sep 15;262(1-2):113-20. doi: 10.1016/j.jneuroim.2013.06.010. Epub 2013 Jul 17.
9
Neuroprotective associations of apolipoproteins A-I and A-II with neurofilament levels in early multiple sclerosis.载脂蛋白 A-I 和 A-II 与早期多发性硬化症中神经丝水平的神经保护相关性。
J Clin Lipidol. 2020 Sep-Oct;14(5):675-684.e2. doi: 10.1016/j.jacl.2020.07.001. Epub 2020 Jul 9.
10
Dimethyl fumarate decreases neurofilament light chain in CSF and blood of treatment naïve relapsing MS patients.富马酸二甲酯可降低未经治疗的复发型多发性硬化症患者脑脊液和血液中的神经丝轻链。
J Neurol Neurosurg Psychiatry. 2019 Dec;90(12):1324-1330. doi: 10.1136/jnnp-2019-321321. Epub 2019 Oct 13.

引用本文的文献

1
Emerging biomarkers in amyotrophic lateral sclerosis: from pathogenesis to clinical applications.肌萎缩侧索硬化症中的新兴生物标志物：从发病机制到临床应用
Front Mol Biosci. 2025 Jun 30;12:1608853. doi: 10.3389/fmolb.2025.1608853. eCollection 2025.
2
Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions.神经退行性疾病中靶向小胶质细胞的生物标志物与治疗策略：现状与未来方向
Mol Neurodegener. 2025 Jul 10;20(1):82. doi: 10.1186/s13024-025-00867-4.
3
Effects of obesity on plasma biomarker and amyloid PET trajectories in Alzheimer's disease.

本文引用的文献

1
Neurofilament light chain as a biomarker in neurological disorders.神经丝轻链作为神经紊乱的生物标志物。
J Neurol Neurosurg Psychiatry. 2019 Aug;90(8):870-881. doi: 10.1136/jnnp-2018-320106. Epub 2019 Apr 9.
2
Neurofilaments as biomarkers in neurological disorders.神经丝作为神经紊乱的生物标志物。
Nat Rev Neurol. 2018 Oct;14(10):577-589. doi: 10.1038/s41582-018-0058-z.
3
Monitoring disease activity in multiple sclerosis using serum neurofilament light protein.使用血清神经丝轻链蛋白监测多发性硬化症的疾病活动
肥胖对阿尔茨海默病血浆生物标志物及淀粉样蛋白PET轨迹的影响。
Alzheimers Dement (Amst). 2025 Jul 3;17(3):e70143. doi: 10.1002/dad2.70143. eCollection 2025 Jul-Sep.
4
Plasma NfL and GFAP for predicting VCI and related brain changes in community and clinical cohorts.血浆神经丝轻链蛋白（NfL）和胶质纤维酸性蛋白（GFAP）用于预测社区和临床队列中的血管性认知障碍（VCI）及相关脑改变。
Alzheimers Dement. 2025 Jun;21(6):e70381. doi: 10.1002/alz.70381.
5
Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview.神经丝定量在神经系统疾病中的临床应用与报告：全球概述
Alzheimers Dement. 2025 Jun;21(6):e70343. doi: 10.1002/alz.70343.
6
Exploring the Clinical Utility of Neurofilament Light Chain Assays in Multiple Sclerosis Management.探索神经丝轻链检测在多发性硬化症管理中的临床应用价值。
Neurol Neuroimmunol Neuroinflamm. 2025 Jul;12(4):e200427. doi: 10.1212/NXI.0000000000200427. Epub 2025 Jun 18.
7
Evaluating Glial Fibrillary Acidic Protein and Neurofilament Light as Potential Biomarkers for Spinocerebellar Ataxia 7.评估胶质纤维酸性蛋白和神经丝轻链作为脊髓小脑共济失调7型潜在生物标志物的作用。
Int J Mol Sci. 2025 May 24;26(11):5070. doi: 10.3390/ijms26115070.
8
Multimorbidity and fluid biomarkers of Alzheimer's disease: a systematic review.阿尔茨海默病的多重疾病与生物标志物：一项系统综述。
Eur Geriatr Med. 2025 May 20. doi: 10.1007/s41999-025-01222-y.
9
Serum glial fibrillary protein reflects early brain injury dynamics and cognitive changes after deep brain stimulation surgery.血清胶质纤维酸性蛋白反映了脑深部电刺激手术后早期脑损伤动态变化及认知改变。
Sci Rep. 2025 May 13;15(1):16537. doi: 10.1038/s41598-025-00399-3.
10
The relationship between neurofilament light chain and depressive symptoms according to cognitive status.根据认知状态，神经丝轻链与抑郁症状之间的关系。
Alzheimers Dement (N Y). 2025 May 8;11(2):e70048. doi: 10.1002/trc2.70048. eCollection 2025 Apr-Jun.
Neurology. 2017 Nov 28;89(22):2230-2237. doi: 10.1212/WNL.0000000000004683. Epub 2017 Oct 27.
4
Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome.血清神经丝轻链是人类脊髓损伤严重程度和预后的生物标志物。
J Neurol Neurosurg Psychiatry. 2015 Mar;86(3):273-9. doi: 10.1136/jnnp-2013-307454. Epub 2014 Jun 16.
5
Smoking and multiple sclerosis susceptibility.吸烟与多发性硬化易感性。
Eur J Epidemiol. 2013 Nov;28(11):867-74. doi: 10.1007/s10654-013-9853-4. Epub 2013 Oct 22.
6
Prediction of blood volume in normal human adults.正常成年人血容量的预测。
Surgery. 1962 Feb;51(2):224-32.
7
A Swedish national post-marketing surveillance study of natalizumab treatment in multiple sclerosis.一项在多发性硬化症中使用那他珠单抗的瑞典全国上市后监测研究。
Mult Scler. 2011 Jun;17(6):708-19. doi: 10.1177/1352458510394701. Epub 2011 Jan 12.