R-(-)-carvone Attenuated Doxorubicin Induced Cardiotoxicity and Potentiated Its Anticancer Toxicity .

BACKGROUND

Doxorubicin is one of the most potent broad-spectrum antitumor and chemotherapeutic agents. However, it produces cardiotoxicity.

AIMS

To investigate whether R-(-)-carvone exerts a cardioprotective effect against doxorubicin toxicity and .

STUDY DESIGN

Cell culture and animal experiment.

METHODS

The synergistic effect of R-(-)-carvone with doxorubicin was evaluated in the MCF 7 cancer cell line while its protective effect against doxorubicin toxicity was evaluated in the normal heart cell line (H9C2) and . Furthermore, the mechanism of its cardioprotective effect was studied.

RESULTS

R-(-)-carvone exerted cytotoxic action on the MCF 7 cancer cell line with an IC value of 14.22 μM and potentiated the cytotoxic action of doxorubicin, while it decreased the toxicity of doxorubicin on a normal heart cell line. In BALB/c mice, R-(-)-carvone protected the heart from the toxic action of doxorubicin, as was evident by biochemical and histological studies. The protective effect of R-(-)-carvone on the H9C2 heart cell line and on heart was due to an increase in catalase activity.

CONCLUSION

R-(-)-carvone has synergistic anticancer action with doxorubicin on the MCF 7 cell line while decreasing its cardiotoxicity.