基于给体-受体共轭聚合物的纳米粒子在近红外二区用于高效光声成像和光热治疗。
Donor-acceptor conjugated polymer-based nanoparticles for highly effective photoacoustic imaging and photothermal therapy in the NIR-II window.
机构信息
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China.
出版信息
Chem Commun (Camb). 2020 Jan 23;56(7):1093-1096. doi: 10.1039/c9cc07821e.
We prepared novel conjugated polymer based NIR-II nanoparticles, which display extremely high photothermal conversion efficiency (65%). Both in vitro and in vivo investigations revealed that the as-prepared nanoparticles exhibit excellent theranostic properties including an extremely high cancer cell killing ability, admirable tumor elimination efficiency (100%) and a remarkable photoacoustic imaging contrast enhancing ability.
我们制备了新型的基于共轭聚合物的近红外二区纳米粒子，其光热转换效率（65%）极高。体外和体内研究均表明，所制备的纳米粒子具有优异的治疗诊断性能，包括极高的癌细胞杀伤能力、令人钦佩的肿瘤消除效率（100%）和显著的光声成像对比度增强能力。
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