McGuinness E E, Wormsley K G
Cancer Lett. 1986 Jul;32(1):73-81. doi: 10.1016/0304-3835(86)90041-8.
Continuous administration of a diet consisting of raw soya flour produces pancreatic cancer in rats and sensitises the rat pancreas to the action of genotoxic carcinogens. We have therefore studied the effects of continuous feeding of diets containing lesser amounts of raw soya flour (5%, 25% and 50%) and feeding raw soya flour intermittently (2 days each week). The study has shown that a diet containing as little as 5% raw soya flour stimulates focal proliferation of the pancreatic acinar cells and sensitises to the action of azaserine. Similarly, intermittent feeding of raw soya flour induced focal proliferation of the acinar pancreas and, when 100% raw soya flour diet was fed for 2 days each week, resulted in the development of pancreatic cancer in some of the rats. We conclude that raw soya flour must be excluded from the diets of rats used in toxicological and carcinogenicity studies.
持续给大鼠喂食由生大豆粉组成的饮食会导致大鼠患胰腺癌，并使大鼠胰腺对基因毒性致癌物的作用敏感。因此，我们研究了持续喂食含较少量生大豆粉（5%、25%和50%）的饮食以及间歇性喂食生大豆粉（每周2天）的影响。研究表明，含低至5%生大豆粉的饮食会刺激胰腺腺泡细胞的局灶性增殖，并使其对重氮丝氨酸的作用敏感。同样，间歇性喂食生大豆粉会诱导胰腺腺泡的局灶性增殖，并且当每周2天喂食100%生大豆粉饮食时，一些大鼠会患上胰腺癌。我们得出结论，在毒理学和致癌性研究中使用的大鼠饮食必须排除生大豆粉。
