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一名年轻女性的急性心肌梗死:冠状动脉闭塞的意外发现。

Acute myocardial infarction in a young woman: Unexpected findings of a coronary occlusion.

作者信息

Zhao Shuquan, Zhu Longlong, Tinzin Lopsong, Huang Fang, Ma Longda, Zhou Yiwu

机构信息

Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, PR China.

Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, PR China.

出版信息

Leg Med (Tokyo). 2020 Feb;42:101662. doi: 10.1016/j.legalmed.2019.101662. Epub 2019 Dec 12.

DOI:10.1016/j.legalmed.2019.101662
PMID:31896072
Abstract

In clinical and forensic practice, the cause of death is often attributed to acute myocardial infarction, among which the coronary atherosclerosis being the Captain of the Men of Death. However, other reasons such as coronary septic embolization with neutrophilic granulocyte myocarditis although rare, can also cause sudden unexpected death. This paper reports a case with this rare cause-a 21-year-old woman diagnosed with "acute gastroenteritis" who died 4 days later. A forensic autopsy revealed an inflammatory polypous embolic located at 1.0 cm from the left anterior descending branch (LAD) with serve neutrophilic granulocyte myocarditis, which resulted in embolic at the opening of the left main coronary artery, acute myocardial infarction and eventually leading to her death. Histopathological examination showed large amounts of neutrophilic granulocyte infiltration in the arterial layer forming the septic embolic and eventually resulting in coronary occlusion. To find the real cause of septic embolic, myocarditis, bacterial, fungal, protozoan and virus detection was performed through RT-PCR, with negative findings. Septic embolic leading coronary occlusion in left main coronary artery and LAD is rarely reported in forensic practice, we hope this report can pave the way on understanding this rare disease to make correct diagnosis in medical practice.

摘要

在临床和法医实践中,死亡原因常被归因于急性心肌梗死,其中冠状动脉粥样硬化是“死亡之因”。然而,其他原因如伴有嗜中性粒细胞性心肌炎的冠状动脉脓毒性栓塞虽罕见,但也可导致猝死。本文报告了一例由这种罕见原因导致的病例——一名21岁女性被诊断为“急性肠胃炎”,4天后死亡。法医尸检发现距左前降支(LAD)1.0厘米处有一个炎性息肉样栓子,伴有严重的嗜中性粒细胞性心肌炎,导致左主冠状动脉开口处栓子形成、急性心肌梗死,最终导致其死亡。组织病理学检查显示动脉层有大量嗜中性粒细胞浸润,形成脓毒性栓子,最终导致冠状动脉闭塞。为找出脓毒性栓子的真正病因,通过逆转录聚合酶链反应(RT-PCR)进行了细菌、真菌、原生动物和病毒检测,结果均为阴性。左主冠状动脉和左前降支因脓毒性栓子导致冠状动脉闭塞在法医实践中鲜有报道,我们希望本报告能为了解这种罕见疾病以及在医疗实践中做出正确诊断提供帮助。

相似文献

1
Acute myocardial infarction in a young woman: Unexpected findings of a coronary occlusion.一名年轻女性的急性心肌梗死:冠状动脉闭塞的意外发现。
Leg Med (Tokyo). 2020 Feb;42:101662. doi: 10.1016/j.legalmed.2019.101662. Epub 2019 Dec 12.
2
Sudden death associated with silent myocardial infarction in a 35-year-old man: a case report.一名35岁男性因无症状心肌梗死导致的猝死:病例报告
J Med Case Rep. 2016 Feb 29;10:46. doi: 10.1186/s13256-016-0823-9.
3
[Acute myocardial infarction due to septic emboli in a patient with severe pneumonia: a case report].[一名重症肺炎患者因脓毒性栓子导致急性心肌梗死:病例报告]
J Cardiol. 2004 Jan;43(1):31-6.
4
Sudden death in the young. Is acute coronary thrombosis the major precipitating factor?年轻人猝死。急性冠状动脉血栓形成是主要诱发因素吗?
Circulation. 1994 Nov;90(5):2315-23. doi: 10.1161/01.cir.90.5.2315.
5
Spontaneous dissection of the distal obtuse marginal coronary artery: a rare cause of sudden death.钝缘支冠状动脉远端自发性夹层:猝死的罕见原因。
Am J Forensic Med Pathol. 2008 Jun;29(2):199-201. doi: 10.1097/PAF.0b013e318174f0fa.
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Sudden unexpected death resulting from an anomalous hypoplastic left coronary artery.异常左冠状动脉发育不全导致的意外猝死。
J Forensic Sci. 1998 May;43(3):708-11.
7
Coronary atherosclerosis and thrombosis underlying acute myocardial infarction.急性心肌梗死潜在的冠状动脉粥样硬化和血栓形成。
Cardiol Clin. 1987 Feb;5(1):21-30.
8
Acute myocardial infarction in the neonatal period.新生儿期急性心肌梗死
Cardiol Young. 2002 Jul;12(4):411-3. doi: 10.1017/s1047951100013068.
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[Coronary artery anomalies as a cause of sudden death in young people].[冠状动脉异常作为年轻人猝死的一个原因]
Tidsskr Nor Laegeforen. 2007 Jan 18;127(2):190-2.
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Coronary fibromuscular dysplasia presenting as sudden infant death.表现为婴儿猝死的冠状动脉纤维肌性发育异常
Arch Pathol Lab Med. 1997 Feb;121(2):159-61.

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