Zhao Shuquan, Zhu Longlong, Tinzin Lopsong, Huang Fang, Ma Longda, Zhou Yiwu
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, PR China.
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, PR China.
Leg Med (Tokyo). 2020 Feb;42:101662. doi: 10.1016/j.legalmed.2019.101662. Epub 2019 Dec 12.
In clinical and forensic practice, the cause of death is often attributed to acute myocardial infarction, among which the coronary atherosclerosis being the Captain of the Men of Death. However, other reasons such as coronary septic embolization with neutrophilic granulocyte myocarditis although rare, can also cause sudden unexpected death. This paper reports a case with this rare cause-a 21-year-old woman diagnosed with "acute gastroenteritis" who died 4 days later. A forensic autopsy revealed an inflammatory polypous embolic located at 1.0 cm from the left anterior descending branch (LAD) with serve neutrophilic granulocyte myocarditis, which resulted in embolic at the opening of the left main coronary artery, acute myocardial infarction and eventually leading to her death. Histopathological examination showed large amounts of neutrophilic granulocyte infiltration in the arterial layer forming the septic embolic and eventually resulting in coronary occlusion. To find the real cause of septic embolic, myocarditis, bacterial, fungal, protozoan and virus detection was performed through RT-PCR, with negative findings. Septic embolic leading coronary occlusion in left main coronary artery and LAD is rarely reported in forensic practice, we hope this report can pave the way on understanding this rare disease to make correct diagnosis in medical practice.
在临床和法医实践中,死亡原因常被归因于急性心肌梗死,其中冠状动脉粥样硬化是“死亡之因”。然而,其他原因如伴有嗜中性粒细胞性心肌炎的冠状动脉脓毒性栓塞虽罕见,但也可导致猝死。本文报告了一例由这种罕见原因导致的病例——一名21岁女性被诊断为“急性肠胃炎”,4天后死亡。法医尸检发现距左前降支(LAD)1.0厘米处有一个炎性息肉样栓子,伴有严重的嗜中性粒细胞性心肌炎,导致左主冠状动脉开口处栓子形成、急性心肌梗死,最终导致其死亡。组织病理学检查显示动脉层有大量嗜中性粒细胞浸润,形成脓毒性栓子,最终导致冠状动脉闭塞。为找出脓毒性栓子的真正病因,通过逆转录聚合酶链反应(RT-PCR)进行了细菌、真菌、原生动物和病毒检测,结果均为阴性。左主冠状动脉和左前降支因脓毒性栓子导致冠状动脉闭塞在法医实践中鲜有报道,我们希望本报告能为了解这种罕见疾病以及在医疗实践中做出正确诊断提供帮助。