Bhattacharyya Ranjan, Chakraborty Kaustav, Sen Arya, Neogi Rajarshi, Bhattacharyya Sumita
Department of Psychiatry, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India.
Department of Psychiatry, College of Medicine and JNM Hospital, Kalyani, Nadia, West Bengal, India.
Indian J Psychiatry. 2019 Nov-Dec;61(6):618-622. doi: 10.4103/psychiatry.IndianJPsychiatry_459_18.
Temperament in children and adolescents acts as a trait marker which can predict behavioral abnormalities. There was no systemic study in India which has compared the temperamental, behavioral and cognitive changes associated with this hemoglobinopathy among thalassemia major (TM) group.
The specific objectives of this study were to find the clinicodemographic profile of individuals and parents, the behavioral, temperamental profile of children of beta TM and correlation of temperamental profile with number of blood transfusions, cognitive profile of children having beta TM, minor and age-matched control children and adolescents.
Child and adolescents having TM have more temperamental and behavioral problems ( < 0.001) and have more psychopathology in comparison to Tm group. Descriptive statistics of the groups and group comparison (ANOVA) shows statistically significant difference in Temperament Measurement Schedule (TMS) total, CPMS total, TMT A, TMT B, and Children's Depression Rating Scale (CDRS) scales ( = 0.000). Descriptive statistics and group comparison (Chi-square test) show significance in number of blood transfusions not with other parameters ( < 0.001). Comparison between TM (Case) and Tm (Control) (-test) shows significance with only TMS total and CPMS scales, not in other scales. The correlation matrix showed significant correlation in-between all the parameters (blood transfusion, TMS, CPMS, TMT A, TMT B, and CDRS).
Those who have been diagnosed as TM have more behavioral and cognitive problems than their comparators. Youngsters receiving more blood transfusions due to their ailments scored higher in childhood depression rating scale.
The temperamental, behavioural and cognitive profile are key determinants of both internalizing and externalizing symptoms and management plan can be guided accordingly as reflected in this study.
儿童和青少年的气质作为一种特质标记，可预测行为异常。在印度，尚无系统性研究比较重型地中海贫血（TM）组中与这种血红蛋白病相关的气质、行为和认知变化。
本研究的具体目标是了解个体及其父母的临床人口统计学特征、β型TM患儿的行为和气质特征、气质特征与输血次数的相关性、β型TM患儿、轻型患儿以及年龄匹配的对照儿童和青少年的认知特征。
与Tm组相比，患有TM的儿童和青少年有更多的气质和行为问题（P<0.001），且精神病理学问题更多。各组的描述性统计和组间比较（方差分析）显示，气质测量量表（TMS）总分、儿童人格问卷修订版（CPMS）总分、追踪测验A（TMT A）、追踪测验B（TMT B）和儿童抑郁评定量表（CDRS）各量表存在统计学显著差异（P = 0.000）。描述性统计和组间比较（卡方检验）显示，输血次数有显著差异，其他参数无显著差异（P<0.001）。TM（病例组）和Tm（对照组）之间的比较（t检验）显示，仅TMS总分和CPMS量表有显著差异，其他量表无显著差异。相关矩阵显示所有参数（输血、TMS、CPMS、TMT A、TMT B和CDRS）之间存在显著相关性。
被诊断为TM的患者比对照组有更多的行为和认知问题。因疾病接受更多输血的青少年在儿童抑郁评定量表上得分更高。
气质、行为和认知特征是内化和外化症状的关键决定因素，本研究表明，管理计划可据此进行指导。
