Yetim Şahin Aylin, Kandemir Ibrahim, Dağ Hüseyin, Türkkan Emine, Tuğrul Aksakal Melike, Sahin Memduh, Baş Firdevs, Karakaş Zeynep
Department of Pediatrics, Division of Adolescent Medicine, Faculty of Medicine, Istanbul University, 34452 Istanbul, Turkey.
Department of Pediatrics, Faculty of Medicine, Biruni University, 34452 Istanbul, Turkey.
Children (Basel). 2024 Jul 9;11(7):837. doi: 10.3390/children11070837.
We investigated depression and anxiety levels and related psychological disorders in adolescents with transfusion-dependent thalassemia (TDT) in this study. The study was conducted in two pediatric hematology outpatient clinics and included adolescents with TDT (14.8 ± 2.4 years, n = 40) in the study and compared them with the healthy age-matched control group (14.3 ± 2.3 years, n = 62). The Turkish version of the Revised Child Anxiety and Depression Scale (RCADS) was used to determine depression, anxiety, and related psychologic disorders (obsession, panic disorder, social phobia). Depression, anxiety, obsession, panic disorder, and social phobia scores were significantly higher in the patient group compared with the control (all < 0.05). Ferritin levels were positively correlated with total depression, general anxiety, separation anxiety, and social phobia scores, but transfusion frequency and young age were the confounding factors. Patients in early adolescence and those who require more frequent blood transfusions are at higher risk of developing psychological disorders; routine screening for mood disorders should be warranted. Serum ferritin level may be a good warning indicator for early recognition of psychologic disorders in TDT patients.
在本研究中，我们调查了依赖输血的地中海贫血（TDT）青少年的抑郁和焦虑水平以及相关心理障碍。该研究在两家儿科血液科门诊进行，研究纳入了TDT青少年（14.8±2.4岁，n = 40），并将他们与年龄匹配的健康对照组（14.3±2.3岁，n = 62）进行比较。使用修订版儿童焦虑与抑郁量表（RCADS）的土耳其语版本来确定抑郁、焦虑及相关心理障碍（强迫症、惊恐障碍、社交恐惧症）。与对照组相比，患者组的抑郁、焦虑、强迫症、惊恐障碍和社交恐惧症得分显著更高（均P<0.05）。铁蛋白水平与总抑郁、广泛性焦虑、分离焦虑和社交恐惧症得分呈正相关，但输血频率和年龄较小是混杂因素。青春期早期的患者以及需要更频繁输血的患者发生心理障碍的风险更高；应进行情绪障碍的常规筛查。血清铁蛋白水平可能是早期识别TDT患者心理障碍的良好警示指标。
