Wang Junyan, Huang Yijuan, Sun Yanbao, Ge Yuxi, Zhang Minming
Department of Radiology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China.
Department of Radiology, The First Hospital of Jiaxing, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China.
Oncol Lett. 2020 Jan;19(1):869-875. doi: 10.3892/ol.2019.11129. Epub 2019 Nov 21.
Desmoid-type fibromatosis is a rare type of soft-tissue tumor originating from connective tissue of the fascia or aponeurosis, which exhibits aggressive growth, high likelihood of relapse and less frequent distant metastasis. The present study aimed to predict the recurrence rate and time by retrospectively analyzing the clinical data (sex, age and recurrence time), imaging findings [tumor location, maximum diameter, border, computed tomography (CT) enhancement ratio, magnetic resonance enhancement ratio and T2 signal ratio] and pathological features (Ki-67 and microscopic margin) in a total of 102 cases of pathologically confirmed desmoid-type fibromatosis. The risk ratio of each factor was calculated using the Cox proportional hazards regression model and the cumulative recurrence-free survival rate was determined using the Kaplan-Meier method and the log-rank test. The cohort comprised of 73 females and 29 males, with mean age of 32.86±12.64 years (range, 6-78 years). The 1-year and 2-year recurrence rate was 31 and 54%, respectively. The median age at recurrence was 29 years. Univariate analysis indicated that sex, maximum tumor diameter, CT enhancement ratio and Ki-67 had a significant effect on the recurrence time. Furthermore, multivariate analysis revealed that sex, maximum tumor diameter, Ki-67 and T2 signal ratio were independently associated with the time of recurrence, and the risk ratios were 0.424, 1.100, 1.084 and 1.268, respectively. Therefore, in male patients with a larger maximum tumor diameter, positivity for Ki-67 and a higher T2 signal ratio, desmoid-type fibromatosis was more likely to recur after surgery.
韧带样型纤维瘤病是一种罕见的软组织肿瘤，起源于筋膜或腱膜的结缔组织，具有侵袭性生长、高复发可能性和较少发生远处转移的特点。本研究旨在通过回顾性分析102例经病理证实的韧带样型纤维瘤病患者的临床资料（性别、年龄和复发时间）、影像学表现[肿瘤位置、最大直径、边界、计算机断层扫描（CT）增强率、磁共振增强率和T2信号率]以及病理特征（Ki-67和显微镜下切缘）来预测复发率和复发时间。使用Cox比例风险回归模型计算各因素的风险比，并使用Kaplan-Meier方法和对数秩检验确定累积无复发生存率。该队列包括73名女性和29名男性，平均年龄为32.86±12.64岁（范围为6 - 78岁）。1年和2年复发率分别为31%和54%。复发的中位年龄为29岁。单因素分析表明，性别、肿瘤最大直径、CT增强率和Ki-67对复发时间有显著影响。此外，多因素分析显示，性别、肿瘤最大直径、Ki-67和T2信号率与复发时间独立相关，风险比分别为0.424、1.100、1.084和1.268。因此，对于最大肿瘤直径较大、Ki-67阳性且T2信号率较高的男性患者，韧带样型纤维瘤病术后更易复发。
