Asaad Saywan K, Abdullah Ari M, Abdalrahman Shkar Ali, Fattah Fattah H, Tahir Soran H, Omer Choman Sabah, Rashid Rezheen J, Hassan Marwan N, Mohammed Shvan H, Kakamad Fahmi H, Abdalla Berun A
Department of Scientific Affairs, Smart Health Tower, Sulaimani, Kurdistan 46001, Iraq.
College of Medicine, University of Sulaimani, Sulaimani, Kurdistan 46001, Iraq.
Mol Clin Oncol. 2023 Sep 7;19(4):84. doi: 10.3892/mco.2023.2680. eCollection 2023 Oct.
Aggressive fibromatosis is a rare clonal proliferative tumor arising from mesenchymal cells in the fascia and musculoaponeurotic structures. The aim of the present study was to describe several cases of extra-abdominal recurrent aggressive fibromatosis. The present study was a single-center retrospective case series of patients with recurrent aggressive fibromatosis. The cases were managed at a single private facility. A total of 9 patients with recurrent fibromatosis were included. The mean and median ages of the patients were 29 and 30 years, respectively. In total, two thirds (66.67%) of the cases were female. A negative previous medical history was reported in 7 cases (77.7%), and diabetes and hypertension were reported in 1 case (11.1%). Overall, only 1 case (11.1%) had a family history of breast fibromatosis. The time interval between primary tumor resection and recurrent presentation was 28 months. In 6 cases (66.7%), the tumor was located in the extremities. Pain was the most common presenting symptom in 6 cases (66.7%). All patients had their recurring tumor surgically removed, followed by radiation in 5 cases. The resection margin was positive in 4 cases (44.4%). Each patient was subjected to a careful three-month follow-up for recurrences. On the whole, the present study demonstrates that despite the fact that several therapeutic approaches for extra-abdominal recurrent aggressive fibromatosis have been described in the literature, there is a significant likelihood of recurrence following resection.
侵袭性纤维瘤病是一种罕见的克隆性增殖性肿瘤，起源于筋膜和肌-腱膜结构中的间充质细胞。本研究的目的是描述几例腹外复发性侵袭性纤维瘤病病例。本研究是一项针对复发性侵袭性纤维瘤病患者的单中心回顾性病例系列研究。这些病例在一家私立机构接受治疗。共纳入9例复发性纤维瘤病患者。患者的平均年龄和中位年龄分别为29岁和30岁。总体而言，三分之二（66.67%）的病例为女性。7例（77.7%）报告既往病史阴性，1例（11.1%）报告有糖尿病和高血压。总体而言，只有1例（11.1%）有乳腺纤维瘤病家族史。原发肿瘤切除与复发表现之间的时间间隔为28个月。6例（66.7%）肿瘤位于四肢。6例（66.7%）最常见的首发症状是疼痛。所有患者均接受了复发性肿瘤的手术切除，其中5例术后接受了放疗。4例（44.4%）切缘阳性。对每位患者进行了为期三个月的仔细随访以观察复发情况。总体而言，本研究表明，尽管文献中已描述了几种针对腹外复发性侵袭性纤维瘤病的治疗方法，但切除术后仍有显著的复发可能性。
