Hematology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
J Bone Miner Metab. 2020 Mar;38(2):145-150. doi: 10.1007/s00774-019-01075-z. Epub 2020 Jan 2.
The bone marrow (BM) is located inside the bone. Now, it appears that bone tissue functionally communicates with the BM hematopoietic system. Osteoblast lineage cells serve as a part of the microenvironment for immature hematopoietic (stem/progenitor) cells. In contrast, mature hematopoietic cells such as neutrophils and macrophages play a critical role to regulate osteoblast activity. A progressive distortion of this precise inter-organ communication between hematopoietic and skeletal systems may lead to hematologic disorders. Recent studies have revealed that vitamin D receptor is a pivotal bridging molecule for this network and for the pathogenesis of myelofibrosis.
骨髓（BM）位于骨内。现在，似乎骨组织与 BM 造血系统在功能上进行通讯。成骨细胞谱系细胞作为未成熟造血（干/祖）细胞的微环境的一部分。相比之下，成熟的造血细胞，如中性粒细胞和巨噬细胞，在调节成骨细胞活性方面发挥着关键作用。这种造血和骨骼系统之间精确的器官间通讯的逐渐扭曲可能导致血液疾病。最近的研究表明，维生素 D 受体是该网络以及骨髓纤维化发病机制的关键桥接分子。
