Asada Noboru, Katayama Yoshio
Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan,
Int J Hematol. 2014 Jun;99(6):679-84. doi: 10.1007/s12185-014-1583-1. Epub 2014 Apr 24.
After birth, the hematopoietic system develops along with bone formation in mammals. Osteolineage cells are derived from mesenchymal progenitor cells, and differentiate into several types of bone-forming cells. Of the various types of cell constituents in bone marrow, osteolineage cells have been shown to play important roles in hematopoiesis. Early studies have identified osteoblasts as a hematopoietic stem cell niche component. Since that time, the role of endosteal microenvironment as a critical regulator of hematopoietic stem/progenitor cell (HSC/HPC) behavior has been appreciated particularly under stress conditions, such as cytokine-induced HSC/HPC mobilization, homing/engraftment after bone marrow transplantation, and disease models of leukemia/myelodysplasia. Recent studies revealed that the most differentiated osteolineage cells, i.e., osteocytes, play important roles in the regulation of hematopoiesis. In this review, we provide an overview of recent advances in knowledge of regulatory hematopoietic mechanisms in the endosteal area.
出生后，哺乳动物的造血系统随着骨骼形成而发育。骨系细胞源自间充质祖细胞，并分化为几种类型的成骨细胞。在骨髓的各种细胞成分中，骨系细胞已被证明在造血过程中发挥重要作用。早期研究已将成骨细胞确定为造血干细胞龛的组成部分。自那时以来，骨内膜微环境作为造血干/祖细胞（HSC/HPC）行为的关键调节因子的作用，尤其在应激条件下，如细胞因子诱导的HSC/HPC动员、骨髓移植后的归巢/植入以及白血病/骨髓增生异常综合征的疾病模型中，已得到认可。最近的研究表明，最分化的骨系细胞，即骨细胞，在造血调节中发挥重要作用。在本综述中，我们概述了骨内膜区域造血调节机制的最新研究进展。
