State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd section, South Renmin Road, Chengdu, 610041, Sichuan, China.
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Clin Rheumatol. 2020 Apr;39(4):1027-1037. doi: 10.1007/s10067-019-04890-x. Epub 2020 Jan 3.
Mitochondrial genes' variants encoded in both the nuclear and mitochondrial genomes can disrupt mitochondrial function, resulting in losing of cartilage and generating osteoarthritis (OA). However, the association between mtDNA haplogroups and OA still lacks strength evidence supporting. The aim of this meta-analysis is to assess the role of mtDNA haplogroups in speculating the pathogenesis and progression of OA. PubMed, Embase, the Cochrane Central Register of Controlled Trials, and World Health Organization clinical trials' registry center were searched to identify relevant studies up to the end of March 2019. Inclusion citations required a case-control or cohort study to demonstrate the association between mtDNA haplogroups and OA's prevalence or progression. Title, abstract, and full-text screening were sequentially assessed by three reviewers. Data were analyzed using STATA. Besides, publication bias and meta-regression analysis were conducted to explore potential heterogeneities. We collected results from 7 articles. The cluster TJ cases showed a lower proportion in OA cases (RR = 0.83, 95% CI 0.72, 0.96). However, there is no evidence that revealed this kind of impact originated from neither type J nor type T individually. Besides, the type B and G analyses among Asian populations also elucidated a negative association. Moreover, the cluster TJ of mtDNA haplogroups revealed a lower cumulative probability of radiographic OA progression (ES = 0.77, 95% CI 0.63, 0.94), which was contributed by type T (ES = 0.61, 95% CI 0.45, 0.82).The mtDNA haplogroups do have impacts on the prevalence and progression of OA. Cluster TJ could help reduce the prevalence and slow down the radiographic changes; however, the impacts came from type J and type T, respectively.
线粒体基因的变体同时编码在线粒体基因组和核基因组中，可以破坏线粒体功能，导致软骨丢失和产生骨关节炎 (OA)。然而，mtDNA 单倍群与 OA 之间的关联仍然缺乏强有力的证据支持。本荟萃分析的目的是评估 mtDNA 单倍群在推测 OA 发病机制和进展中的作用。我们检索了 PubMed、Embase、Cochrane 中心对照试验注册库和世界卫生组织临床试验注册中心，以确定截至 2019 年 3 月底的相关研究。纳入的文献需要一项病例对照或队列研究，以表明 mtDNA 单倍群与 OA 的患病率或进展之间存在关联。三位评审员依次对标题、摘要和全文进行筛选。使用 STATA 分析数据。此外，还进行了发表偏倚和荟萃回归分析，以探索潜在的异质性。我们从 7 篇文章中收集结果。集群 TJ 病例在 OA 病例中的比例较低（RR=0.83，95%CI 0.72，0.96）。然而，没有证据表明这种影响来自 J 型或 T 型单独。此外，亚洲人群的 B 型和 G 型分析也表明存在负相关。此外，mtDNA 单倍群的集群 TJ 显示放射学 OA 进展的累积概率较低（ES=0.77，95%CI 0.63，0.94），这归因于 T 型（ES=0.61，95%CI 0.45，0.82）。mtDNA 单倍群确实对 OA 的患病率和进展有影响。集群 TJ 有助于降低患病率并减缓放射学变化；然而，影响来自 J 型和 T 型，分别。
