Nomelini Rosekeila Simões, Carrijo Chiovato Ana Flávia, Abdulmassih Fernanda Beatriz Ferreira, da Silva Rafael de Carvalho, Tavares-Murta Beatriz Martins, Murta Eddie Fernando Candido
Department of Maternal-Child, Research Institute of Oncology (IPON)/Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, Minas Gerais State, Uberaba-MG, Brazil.
Department of Biochemistry, Pharmacology and Physiology, Research Institute of Oncology (IPON)/Discipline of Pharmacology, Federal University of Triangulo Mineiro, Uberaba-MG, Brazil.
J Cancer Res Ther. 2019 Oct-Dec;15(6):1226-1230. doi: 10.4103/jcrt.JCRT_304_17.
The objectives of the present study were to demonstrate the influence of neutrophils, platelets, and neutrophil-lymphocyte ratio (NLR) in the ovarian cancer prognosis and to compare these parameters with benign ovarian neoplasms.
Records of patients underwent surgery for ovarian cysts were evaluated. There were 72 malignant neoplasms and 213 benign neoplasms. Age, parity, histologic type, tumor stage, type of surgery performed, chemotherapy, disease-free survival, serum levels of tumor markers, neutrophils, lymphocytes, platelets, and NRL were recorded. The Mann-Whitney, the Chi-square test and multiple linear regression were used. A P-value < 0.05 was established as the significance level.
Higher values of platelets, neutrophils, and NLR were found in malignant tumors (P = 0.0132, P = 0.0208, and P < 0.0001, respectively), while lymphocytes values were higher in benign group (P < 0.0001). Preoperative platelet count 300,000/mm3 was related to less aggressive histological types (P = 0.0148). NLR <3 was related to the initial stages (P = 0.0053), and patients with disease-free survival >24 months had most often neutropenia during chemotherapy (P = 0.0482). After multivariate analysis, platelets, NLR, and serum levels of CA15.3 were considered independent variables related to tumor staging (P = 0.028, P = 0.028, and P = 0.035, respectively).
NLR and serum levels of platelets may represent potential prognostic factors in ovarian cancer, and they may also serve as therapeutic targets in the future treatment strategies.
本研究的目的是证明中性粒细胞、血小板和中性粒细胞与淋巴细胞比值（NLR）对卵巢癌预后的影响，并将这些参数与良性卵巢肿瘤进行比较。
评估接受卵巢囊肿手术患者的记录。其中有72例恶性肿瘤和213例良性肿瘤。记录患者的年龄、产次、组织学类型、肿瘤分期、手术类型、化疗情况、无病生存期、肿瘤标志物血清水平、中性粒细胞、淋巴细胞、血小板和NLR。采用曼-惠特尼检验、卡方检验和多元线性回归分析。以P值<0.05为显著性水平。
恶性肿瘤中血小板、中性粒细胞和NLR值较高（分别为P = 0.0132、P = 0.0208和P < 0.0001），而良性组淋巴细胞值较高（P < 0.0001）。术前血小板计数>300,000/mm³与侵袭性较小的组织学类型有关（P = 0.0148）。NLR<3与疾病初期有关（P = 0.0053），无病生存期>24个月的患者在化疗期间最常出现中性粒细胞减少（P = 0.0482）。多因素分析后，血小板、NLR和CA15.3血清水平被认为是与肿瘤分期相关的独立变量（分别为P = 0.028、P = 0.028和P = 0.035）。
NLR和血小板血清水平可能是卵巢癌潜在的预后因素，在未来的治疗策略中也可能作为治疗靶点。
