宫颈癌盆腔及腹主动脉旁淋巴结转移的术前预测因素
Preoperative predictors of pelvic and para-aortic lymph node metastases in cervical cancer.
作者信息
Gulseren Varol, Kocaer Mustafa, Gungorduk Ozgu, Ozdemir Isa Aykut, Gokcu Mehmet, Mart Emre Merter, Sanci Muzaffer, Gungorduk Kemal
机构信息
Department of Obstetrics and Gynecology, Kaman State Hospital, Kırşehir, Turkey.
Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey.
出版信息
J Cancer Res Ther. 2019 Oct-Dec;15(6):1231-1234. doi: 10.4103/jcrt.JCRT_467_17.
AIM
This study investigated potential preoperative predictors of pelvic lymph node (PLN) and para-aortic LN (PaLN) involvement in cervical cancer (CC).
MATERIALS AND METHODS
This study retrospectively analyzed 283 patients diagnosed with early (stage IA1-IIA) CC who underwent retroperitoneal LN dissection between January 1992 and February 2015. Several risk factors that are believed to influence PLN and PaLN involvement in CC were analyzed as follows: age >50 years, lymphovascular space invasion (LVSI), tumor size ≥2 cm, hemoglobin <12 g/dL, and nonsquamous cell histologic type.
RESULTS
LVSI (odds ratio [OR] = 11.3, 95% confidence interval [CI] = 5.2-24.3) and tumor size (OR = 3.2, 95% CI = 1.4-7.2) were independent predictors of PLN involvement. None of the factors predicted PaLN involvement in a regression analysis. However, all nine patients who had PaLN involvement also had PLN involvement.
CONCLUSION
LVSI and tumor size independently increase the risk of PLN involvement.
目的
本研究调查了宫颈癌（CC）患者术前盆腔淋巴结（PLN）及腹主动脉旁淋巴结（PaLN）受累的潜在预测因素。
材料与方法
本研究回顾性分析了1992年1月至2015年2月期间接受腹膜后淋巴结清扫术的283例诊断为早期（IA1-IIA期）CC的患者。分析了如下几种被认为影响CC患者PLN及PaLN受累的危险因素：年龄>50岁、脉管间隙浸润（LVSI）、肿瘤大小≥2 cm、血红蛋白<12 g/dL及非鳞状细胞组织学类型。
结果
LVSI（比值比[OR]=11.3，95%置信区间[CI]=5.2-24.3）及肿瘤大小（OR=3.2，95%CI=1.4-7.2）是PLN受累的独立预测因素。回归分析中无因素可预测PaLN受累。然而，所有9例有PaLN受累的患者均有PLN受累。
结论
LVSI及肿瘤大小独立增加PLN受累风险。
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