Pharmacy Department, Durham Veterans Affairs Health Care System, Durham, NC, USA.
Infect Dis (Lond). 2020 Jun;52(6):381-390. doi: 10.1080/23744235.2019.1708454. Epub 2020 Jan 3.
is one of the most common chronic infections and is a leading cause of gastric cancer. There are currently several short-course treatment options available for the treatment of . However, there has been a significant increase in global resistance patterns for and there is a need for alternative treatment regimens. Nitazoxanide (NTZ) is an anti-protozoal agent that has been evaluated within several studies for the treatment of . The objective of this review is to evaluate the efficacy and safety of NTZ-based treatments for a infection. Pubmed (1946-August 2019) and Embase (1947-August 2019) were queried using the following search terms: , infection, , nitazoxanide, tizoxanide, thiazoles, thiazole derivative and NTZ. Appropriate studies were evaluated with varying treatment regimens and cure rates. Ten studies that utilized a NTZ-based treatment for were identified from the literature search. Eight of the ten studies demonstrated a cure rate of greater than 80% in at least one NTZ-based treatment arm. Gastrointestinal side effects were the most commonly reported adverse drug reaction in the studies. Nitazoxanide-based treatments appear to be an effective treatment for . While the ideal NTZ combination therapy is uncertain, a combination with a proton-pump inhibitor and one to two antibiotics has demonstrated the highest rates of eradication. Nitazoxanide-based treatments are well-tolerated and minimal discontinuation due to side effects were reported in the studies.
幽门螺杆菌感染是最常见的慢性感染之一，也是胃癌的主要病因。目前有几种针对幽门螺杆菌感染的短期治疗方案。然而，全球幽门螺杆菌的耐药模式发生了显著变化，需要替代治疗方案。硝唑尼特（NTZ）是一种抗原生动物药物，已在多项研究中评估用于治疗幽门螺杆菌感染。本综述的目的是评估基于硝唑尼特的治疗方案治疗幽门螺杆菌感染的疗效和安全性。通过以下搜索词在 PubMed（1946 年 8 月至 2019 年）和 Embase（1947 年 8 月至 2019 年）进行检索：，幽门螺杆菌感染，，硝唑尼特，替硝唑，噻唑，噻唑衍生物和 NTZ。评估了不同治疗方案和治愈率的适当研究。从文献检索中确定了 10 项使用基于硝唑尼特的治疗方案治疗幽门螺杆菌感染的研究。这 10 项研究中有 8 项研究表明，在至少一个基于硝唑尼特的治疗组中，治愈率超过 80%。胃肠道不良反应是研究中报告的最常见药物不良反应。基于硝唑尼特的治疗方案似乎是治疗幽门螺杆菌感染的有效方法。虽然理想的 NTZ 联合治疗方案尚不确定，但与质子泵抑制剂和一种至两种抗生素联合使用已显示出最高的幽门螺杆菌根除率。基于硝唑尼特的治疗方案耐受性良好，研究中报告的因不良反应而停药的情况很少。
