Department of Paediatric Rheumatology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ophthalmic Research Center, Shahid Beheshti University of Medicine Sciences, Tehran, Iran.
Eye (Lond). 2020 Oct;34(10):1883-1887. doi: 10.1038/s41433-019-0762-y. Epub 2020 Jan 3.
To assess the incidence of ocular manifestations of Kawasaki disease (KD) in children and to evaluate the relationship between ocular manifestations and the other clinical manifestations, laboratory findings, and echocardiographic findings.
Complete ophthalmologic examination and echocardiography were performed in 36 patients with KD during the acute phase before starting the treatment. Clinical manifestations and laboratory data including white blood cell (WBC) count, neutrophil-to-lymphocyte ratio, platelet count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were obtained from all the patients. All the clinical and laboratory findings were compared between the group with ocular involvement and the one without ocular involvement.
The incidence of bilateral non-exudative conjunctivitis was 63.9%. It was significantly higher in patients with skin rashes (P < 0.05). The incidence of uveitis was 36.1%, which consisted primarily of grade 1+ or 2+ acute anterior uveitis. Neutrophil count and CRP levels were significantly higher in the uveitis group than in the group without uveitis (P < 0.05). Coronary artery dilatation showed significant correlation with uveitis (P < 0.05). Uveitis did not show a significant correlation with other clinical manifestations, ESR, ALT level, AST level, and platelet count (P > 0.05).
In children with Kawasaki disease, uveitis is associated with coronary artery dilatation, higher neutrophil count, and higher CRP level.
评估川崎病（KD）患儿眼部表现的发生率，并评估眼部表现与其他临床表现、实验室检查结果和超声心动图结果之间的关系。
对 36 例 KD 患儿在开始治疗前的急性期进行全面眼科检查和超声心动图检查。从所有患者中获取临床症状和实验室数据，包括白细胞（WBC）计数、中性粒细胞与淋巴细胞比值、血小板计数、红细胞沉降率（ESR）、C 反应蛋白（CRP）以及丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）水平。比较眼部受累组和无眼部受累组之间的所有临床和实验室发现。
双侧非渗出性结膜炎的发生率为 63.9%。在有皮疹的患者中，其发生率明显更高（P<0.05）。葡萄膜炎的发生率为 36.1%，主要为 1+或 2+急性前葡萄膜炎。葡萄膜炎组的中性粒细胞计数和 CRP 水平明显高于无葡萄膜炎组（P<0.05）。冠状动脉扩张与葡萄膜炎有显著相关性（P<0.05）。葡萄膜炎与其他临床表现、ESR、ALT 水平、AST 水平和血小板计数无显著相关性（P>0.05）。
在川崎病患儿中，葡萄膜炎与冠状动脉扩张、中性粒细胞计数升高和 CRP 水平升高有关。
