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维生素C疗法中添加镁增强抗癌效果：通过激活SVCT-2抑制应激反应。

Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation.

作者信息

Cho Sungrae, Chae Jin Sung, Shin Hocheol, Shin Yujeong, Kim Youngwook, Kil Eui-Joon, Byun Hee-Seong, Cho Sang-Ho, Park Seyeon, Lee Sukchan, Yeom Chang-Hwan

机构信息

College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Yeom Chang-Hwan Hospital, Seoul, 06605, Republic of Korea.

出版信息

Transl Oncol. 2020 Feb;13(2):401-409. doi: 10.1016/j.tranon.2019.10.017. Epub 2019 Dec 31.

DOI:10.1016/j.tranon.2019.10.017
PMID:31901552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6940627/
Abstract

l-Ascorbic acid (vitamin C, AA) is known as an antioxidant, but at high concentrations, AA can kill cancer cells through a prooxidant property. Sodium-dependent vitamin C transporter family-2 (SVCT-2) determines the cellular uptake of AA, and the activity of SVCT-2 is directly related to the anticancer activity of AA. Cancer cells that showed high SVCT-2 expression levels were more sensitive to AA treatment than cancer cells with low SVCT-2 expression levels. Cells with low SVCT-2 expression showed a hormetic response to a low dose of AA. Magnesium ions, which are known to activate SVCT-2, could increase the V value of SVCT-2, so we investigated whether providing magnesium supplements to cancer cells with low SVCT-2 expression that had shown a hormetic response to AA would elevate the V value of SVCT-2, allowing more AA to accumulate. To evaluate the effects of magnesium on cancer cells, MgSO and MgCl were screened as magnesium supplements; both forms showed synergistic anticancer effects with AA. Taken together, the results of this study suggest that magnesium supplementation enhanced the anticancer effect of AA by inhibiting the hormetic response at a low dose. This study has also demonstrated that AA treatment with magnesium supplementation provided more effective anticancer therapy than AA treatment alone.

摘要

L-抗坏血酸（维生素C，AA）作为一种抗氧化剂广为人知，但在高浓度时，AA可通过促氧化特性杀死癌细胞。钠依赖性维生素C转运蛋白家族2（SVCT-2）决定了细胞对AA的摄取，且SVCT-2的活性与AA的抗癌活性直接相关。与SVCT-2表达水平低的癌细胞相比，SVCT-2表达水平高的癌细胞对AA治疗更敏感。SVCT-2表达低的细胞对低剂量AA呈现剂量效应。已知可激活SVCT-2的镁离子可增加SVCT-2的V值，因此我们研究了向对AA呈现剂量效应的SVCT-2表达低的癌细胞补充镁是否会提高SVCT-2的V值，使更多AA积累。为评估镁对癌细胞的影响，筛选了MgSO和MgCl作为镁补充剂；两种形式均与AA呈现协同抗癌作用。综上所述，本研究结果表明补充镁通过抑制低剂量时的剂量效应增强了AA的抗癌作用。本研究还证明，补充镁的AA治疗比单独的AA治疗提供了更有效的抗癌疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/faa13666b3a4/gr9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/08fd5a830856/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/839f93dcdb98/gr5.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/9c25ec63eb87/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/faa13666b3a4/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/4e9c4c7a718e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/30f97c601126/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/13f9b215626b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/08fd5a830856/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/839f93dcdb98/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/897f2359e060/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/4598eec3f5c8/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/9c25ec63eb87/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5d/6940627/faa13666b3a4/gr9.jpg

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