Lin Zheng-Yang, Liang Yong-Yi, Wang Ru, Hu Biao, He Wen-Ju, Li Jun-Kui, Ding Zi-Ang, Lin Zhuo-Yuan, Zhang Shi
Department of Clinical Medicine The Second Clinical School of Guangzhou Medical University Guangzhou China.
Department of Preventive Medicine School of Public Health, Guangzhou Medical University Guangzhou China.
Food Sci Nutr. 2023 Jun 1;11(8):4773-4780. doi: 10.1002/fsn3.3456. eCollection 2023 Aug.
The estimated glomerular filtration rate (eGFR) is a comprehensive index that is widely used to assess renal function. Although studies have confirmed a correlation between eGFR and dietary vitamin C, the impact of varying levels of vitamin C on eGFR remains unclear. Additionally, the interaction between dietary magnesium intake and vitamin C concentration on eGFR is not well understood. As such, the objective of this study was to investigate the relationship between dietary magnesium intake and vitamin C in relation to eGFR. This study analyzed the data of consecutive NHANES from 2005 to 2018. We included 17,633 participants aged 20 or older and used multiple linear regression analysis to evaluate the relationship between dietary vitamin C and eGFR. Dietary Mg intake from experimental data was dichotomized into a low dietary Mg intake group (≤254 mg/day) and a normal dietary Mg intake group (>254 mg/day). To evaluate the impact of dietary magnesium intake on eGFR, a multivariable linear regression was conducted utilizing an interaction test between dietary vitamin C and eGFR. We discovered a positive association between dietary vitamin C content and eGFR. The relationship between dietary vitamin C levels and eGFR differed between individuals with low Mg intake and those with normal Mg intake (: 2.96 95% CI:1.63 ~ 4.29 vs. : 1.05 95% CI: -0.15 to 2.25), and the positive association of high dietary vitamin C content with eGFR was stronger in the low Mg intake group. Furthermore, we observed that dietary magnesium intake significantly altered the positive association between dietary vitamin C and eGFR (interaction value of 0.020). Our experimental study revealed that the interaction between dietary magnesium and dietary vitamin C can significantly impact eGFR. This finding carries significant implications for the treatment of diseases resulting from abnormal eGFR, as well as the selection of clinically relevant drugs.
估计肾小球滤过率（eGFR）是一种广泛用于评估肾功能的综合指标。尽管研究已证实eGFR与膳食维生素C之间存在相关性，但不同水平的维生素C对eGFR的影响仍不明确。此外，膳食镁摄入量与维生素C浓度对eGFR的相互作用也尚未得到充分了解。因此，本研究的目的是调查膳食镁摄入量与维生素C与eGFR之间的关系。本研究分析了2005年至2018年连续的美国国家健康与营养检查调查（NHANES）数据。我们纳入了17633名20岁及以上的参与者，并使用多元线性回归分析来评估膳食维生素C与eGFR之间的关系。根据实验数据，将膳食镁摄入量分为低膳食镁摄入量组（≤254毫克/天）和正常膳食镁摄入量组（>254毫克/天）。为了评估膳食镁摄入量对eGFR的影响，利用膳食维生素C与eGFR之间的相互作用测试进行了多变量线性回归。我们发现膳食维生素C含量与eGFR之间存在正相关。低镁摄入量个体和正常镁摄入量个体的膳食维生素C水平与eGFR之间的关系有所不同（分别为：2.96，95%置信区间：1.63至4.29与：1.05，95%置信区间：-0.15至2.25），高膳食维生素C含量与eGFR的正相关在低镁摄入量组中更强。此外，我们观察到膳食镁摄入量显著改变了膳食维生素C与eGFR之间的正相关（相互作用值为0.020）。我们的实验研究表明，膳食镁与膳食维生素C之间的相互作用可显著影响eGFR。这一发现对因eGFR异常导致的疾病治疗以及临床相关药物的选择具有重要意义。
