Department of General Practice, Linyi People's Hospital, Linyi, Shandong, China.
Department of Anus and Intestine Surgery, Taian Central Hospital, Taian, Shandong, China.
J Biomater Sci Polym Ed. 2020 Mar;31(4):549-560. doi: 10.1080/09205063.2020.1712175. Epub 2020 Jan 14.
Eye drop solutions are widely used by the ophthalmologist to treat the anterior segment eye diseases. However, eye drop solutions have many limitations including low bioavailability, high dose requirements, and poor patient compliance. Contact lenses are used to deliver the ocular drugs with high ocular bioavailability due to its immediate location to cornea. To attend controlled and prolonged drug release from the contact lenses, scientists are working on various systems including polymeric nanoparticles, molecular imprinting, microemulsion, micelles, liposomes, implantation, supercritical fluids, and use of vitamin E. However, the changes in the critical lens properties like swelling, optical transparency, ion permeability, tensile strength, oxygen permeability, high burst release, issues during monomer extraction, sterilization and storage are yet to address. The review is focused on the commercial challenges with different methodologies to develop therapeutic contact lenses for commercial market. Many animal and clinical studies are under pipeline and it is likely that the therapeutic contact lenses will be commercialized in next few years.
眼用溶液被眼科医生广泛用于治疗眼前段眼病。然而，眼用溶液有许多局限性，包括生物利用度低、剂量要求高和患者顺应性差。隐形眼镜由于其位置紧邻角膜，因此可用于提供具有高眼部生物利用度的眼部药物。为了从隐形眼镜中实现受控和延长的药物释放，科学家们正在研究各种系统，包括聚合物纳米粒子、分子印迹、微乳液、胶束、脂质体、植入物、超临界流体以及使用维生素 E。然而，隐形眼镜的关键性能（如膨胀、光学透明度、离子渗透性、拉伸强度、氧气渗透性、高突释、单体提取、消毒和储存期间的问题）的变化仍有待解决。本综述重点介绍了不同方法学在开发用于商业市场的治疗性隐形眼镜方面所面临的商业挑战。许多动物和临床研究正在进行中，治疗性隐形眼镜很可能在未来几年内实现商业化。
