土耳其人群中CYP2J2基因多态性与银屑病易感性的关联：一项病例对照研究。
Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study.
作者信息
Hayran Yıldız, Allı Nuran, Uysal Pınar İncel, Çandar Tuba
机构信息
Department of Dermatology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Department of Dermatology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
出版信息
An Bras Dermatol. 2020 Jan-Feb;95(1):25-31. doi: 10.1016/j.abd.2019.04.006. Epub 2019 Dec 10.
BACKGROUND
Cytochrome P450 2J2 is mostly expressed in extrahepatic tissues; it metabolizes arachidonic acid to epoxyeicosatrienoic acids, with various cardio protective and anti-inflammatory effects. CYP2J2 polymorphism has been identified as a risk factor for cardiovascular diseases, but its association with psoriasis remains unknown.
OBJECTIVE
To evaluate CYP2J2 polymorphism as a risk factor for psoriasis in the Turkish population.
METHODS
There were 94 patients with psoriasis and 100 age- and sex-matched healthy controls included in the study. Detailed demographic and clinical characteristics were recorded, and Psoriasis Area and Severity Index (PASI) scores were calculated for psoriasis patients. Venous blood samples were collected from all the participants and CYP2J2 50G>T (rs890293) polymorphism was analyzed using polymerase chain reaction (PCR).
RESULTS
Both T allele and TT+GT genotype frequencies were increased in psoriasis vulgaris patients compared to the control group (p=0.024 and p=0.029 respectively, OR=2.82, 95% CI: 1.11-7.15) No association between CYP2J2 polymorphism and clinical features of psoriasis was identified.
STUDY LIMITATIONS
A limited number of patients were included in the study.
CONCLUSION
CYP2J2 50G>T (rs890293) polymorphism was associated with an increased risk for PsV in the Turkish population.
背景
细胞色素P450 2J2主要在肝外组织中表达；它将花生四烯酸代谢为环氧二十碳三烯酸，具有多种心脏保护和抗炎作用。CYP2J2基因多态性已被确定为心血管疾病的危险因素，但其与银屑病的关联尚不清楚。
目的
评估CYP2J2基因多态性作为土耳其人群银屑病危险因素的情况。
方法
本研究纳入了94例银屑病患者和100例年龄及性别匹配的健康对照。记录详细的人口统计学和临床特征，并计算银屑病患者的银屑病面积和严重程度指数（PASI）评分。采集所有参与者的静脉血样本，采用聚合酶链反应（PCR）分析CYP2J2 50G>T（rs890293）基因多态性。
结果
与对照组相比，寻常型银屑病患者的T等位基因频率和TT+GT基因型频率均升高（分别为p=0.024和p=0.029，OR=2.82，95%CI：1.11-7.15）。未发现CYP2J2基因多态性与银屑病临床特征之间存在关联。
研究局限性
本研究纳入的患者数量有限。
结论
在土耳其人群中，CYP2J2 50G>T（rs890293）基因多态性与寻常型银屑病风险增加有关。
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