营养不良的癌症患者尿中皮质醇和儿茶酚胺排泄增加。
Increased urinary excretion of cortisol and catecholami-NES in malnourished cancer patients.
作者信息
Drott C, Svaninger G, Lundholm K
机构信息
Department of Surgery, University of Gothenburg, Sahlgrenska Hospital, Sweden.
出版信息
Ann Surg. 1988 Nov;208(5):645-50. doi: 10.1097/00000658-198811000-00017.
Excretion of cortisol and catecholamines were measured from 24-hour urine samples collected over a period of 3 days from hospitalized cancer patients suffering from malnutrition and were compared with those of control patients equally malnourished and having a similar degree of inflammation. Compared with control patients, cancer patients had a higher excretion of cortisol, adrenaline, and noradrenaline, although noradrenaline excretion reached statistical significance only when normalized to creatinine excretion. Plasma glycerol concentrations after an overnight fast were significantly higher in cancer patients as compared with control patients, in keeping with an increased adrenal and adrenergic activity. This study demonstrates evidence of simultaneously elevated catecholamine and cortisol excretion in cancer patients, which could not be ascribed to alteration in body composition. The results may, in part, explain the mechanisms behind ongoing tissue breakdown in progressive cancer disease.
从住院的营养不良癌症患者中收集了为期3天的24小时尿液样本，测量其中皮质醇和儿茶酚胺的排泄量，并与同样营养不良且炎症程度相似的对照患者进行比较。与对照患者相比，癌症患者的皮质醇、肾上腺素和去甲肾上腺素排泄量更高，尽管仅在将去甲肾上腺素排泄量标准化为肌酐排泄量时才达到统计学显著性。与对照患者相比，癌症患者在禁食过夜后的血浆甘油浓度显著更高，这与肾上腺和肾上腺素能活性增加一致。这项研究证明了癌症患者儿茶酚胺和皮质醇排泄量同时升高的证据，这不能归因于身体成分的改变。这些结果可能部分解释了进展性癌症疾病中持续组织分解背后的机制。
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