重度运动障碍和震颤患者脑深部电刺激术的术中管理：氯胺酮来帮忙！
Intraoperative Management of a Patient for Deep Brain Stimulation with Severe Dyskinesia and Tremors: Ketamine to the Rescue!
作者信息
Sokhal Suman, Goyal Keshav, Sokhal Navdeep, Kumar Niraj, Kedia Shweta
机构信息
Department of Neuroanaesthesiology and Critical Care, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.
Department Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
出版信息
Asian J Neurosurg. 2019 Nov 25;14(4):1275-1276. doi: 10.4103/ajns.AJNS_47_18. eCollection 2019 Oct-Dec.
The loss of dopaminergic neurons from the substantia nigra pars compacta characterizes the classical pathology of Parkinson's disease (PD). Deep brain stimulation (DBS) has become an increasingly common treatment for PD. Sometimes excessive tremors due to exacerbated PD hinder the surgery and may almost make it impossible. This is a case report highlights use of IV ketamine for intraoperative sedation of a patient with PD, with severe dyskinesia & tremors, posted for DBS. IV ketamine resulted in prompt abolition of tremors and dyskinesia, which were unresponsive to previous traditional sedative drugs.
黑质致密部多巴胺能神经元的丧失是帕金森病（PD）的典型病理特征。深部脑刺激（DBS）已成为治疗PD越来越常用的方法。有时，由于PD病情加重导致的过度震颤会妨碍手术，甚至几乎使其无法进行。这是一例病例报告，重点介绍了静脉注射氯胺酮用于一名患有严重运动障碍和震颤的PD患者在DBS手术中的术中镇静。静脉注射氯胺酮迅速消除了震颤和运动障碍，而这些症状对先前的传统镇静药物无反应。
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