Department of Biotechnology, Mizoram University, Aizawl, Mizoram, 796004, India.
Faculty of Dentistry, McGill University, 2001 McGill College Ave, Montreal, Quebec, H3A 1G1, Canada.
Environ Sci Pollut Res Int. 2020 Mar;27(8):8580-8585. doi: 10.1007/s11356-019-07543-3. Epub 2020 Jan 6.
The study aims to understand the influence of environmental and lifestyle factors and more specifically the role of tobacco smoke-infused water (tuibur) on Helicobacter pylori infection. It was a cross-sectional study to measure the epidemiological risk factors associated with H. pylori infection among the tribal population in Northeast India. Endoscopic samples were collected from the antrum region of the stomach from 863 participants with gastritis. H. pylori infection was confirmed in 475 samples by the rapid urease test and PCR-based methods. Information on demographic and lifestyle factors was collected using a validated and standardized questionnaire. Logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) for the association between the various factors and H. pylori. The use of tuibur was associated with an increased OR of H. pylori infection (OR = 3.32, 95% Cl = 1.95-5.83). Tobacco chewers (OR = 1.49, 95% Cl = 1.06-2.09), smokers (OR = 1.81, 95% Cl = 1.26-2.61), and alcohol consumers (OR = 1.81, 95% Cl = 1.19-2.76) were also infected with H. pylori. The results were not attenuated after adjusting for major well-known risk factors of H. pylori infection. The habit of tuibur consumption may be a contributing factor to the high prevalence of H. pylori infection and in turn, may contribute to the high prevalence of gastritis among the Mizo population.
本研究旨在探讨环境和生活方式因素的影响，尤其是烟草水（tuibur）对幽门螺杆菌感染的作用。这是一项横断面研究，旨在测量与印度东北部部落人群幽门螺杆菌感染相关的流行病学风险因素。从 863 名胃炎患者的胃窦区采集内镜样本。通过快速尿素酶试验和基于 PCR 的方法，在 475 个样本中确认了幽门螺杆菌感染。使用经过验证和标准化的问卷收集了人口统计学和生活方式因素信息。使用逻辑回归估计了各种因素与幽门螺杆菌之间的关联的比值比（OR）和 95％置信区间（CI）。使用 tuibur 与幽门螺杆菌感染的 OR 增加相关（OR=3.32，95％Cl=1.95-5.83）。咀嚼烟草者（OR=1.49，95％Cl=1.06-2.09）、吸烟者（OR=1.81，95％Cl=1.26-2.61）和饮酒者（OR=1.81，95％Cl=1.19-2.76）也感染了幽门螺杆菌。在调整了幽门螺杆菌感染的主要已知危险因素后，结果并未减弱。tuibur 消费习惯可能是幽门螺杆菌感染高发的一个促成因素，反过来也可能导致米佐人群中胃炎的高发。
