Safuan D, Koroleva S A, Dorokhova E A, Ermakova N G
Arkh Patol. 1988;50(7):45-51.
In a series of experiments on 230 noninbred white rats the trend in the development of soft tissue abscess was investigated under stimulation and inhibition of phagocytizing mononuclear cells (PMC). The results suggest the stimulation to promote more reliable localization of the inflammation focus and encapsulation with connective tissue. The test for alpha-naphthyl esterase and quantitation of macrophages (absolute number) per infiltration area unit adjacent to the abscess suggest a direct correlation between the absolute number of macrophages and the width of the capsule. The data obtained confirm the assumptions on the role of macrophages in inflammation focus as a regulatory and controlling factor for cellular reactions. PMC system is shown to affect the process of abscess separation from adjacent tissues including formation of the capsule.
在对230只非近交系白色大鼠进行的一系列实验中，研究了在吞噬单核细胞（PMC）受到刺激和抑制的情况下软组织脓肿的发展趋势。结果表明，刺激可促进炎症病灶更可靠地定位，并由结缔组织包裹。对α-萘酯酶的检测以及对脓肿相邻浸润区域单位面积内巨噬细胞（绝对数量）的定量分析表明，巨噬细胞的绝对数量与包膜宽度之间存在直接相关性。所获得的数据证实了关于巨噬细胞在炎症病灶中作为细胞反应的调节和控制因素的作用的假设。结果表明，PMC系统会影响脓肿与相邻组织的分离过程，包括包膜的形成。
