Smith W A, Hete B F, Kiraly R J, Fujimoto L K, Jacobs G B, Ishikawa M, Butler K, Nosé Y
Cleveland Clinic Foundation, Ohio 44106.
Artif Organs. 1988 Oct;12(5):402-9. doi: 10.1111/j.1525-1594.1988.tb02795.x.
The E4T is a totally implantable total artificial heart (TAH) resulting from many years of research work at the Cleveland Clinic Foundation (CCF) and Nimbus, Inc. It consists of four implanted subsystems: the pumping unit, the variable volume device, the transcutaneous transformer, and the internal battery. The pumping unit consists of two CCF biolized pusher plate pumps, and a Nimbus electrohydraulic energy converter. The control logic is based on a left master, alternating beating scheme. The timing difference between end right eject and end left fill determines the actuator speed adjustment. The pumps free fill, so left-right flow differences are easily accommodated. A prototype system has been built and begun testing to validate and refine the design details.
E4T是一款完全植入式全人工心脏（TAH），它是克利夫兰诊所基金会（CCF）和Nimbus公司多年研究工作的成果。它由四个植入子系统组成：泵单元、可变容积装置、经皮变压器和内置电池。泵单元由两个CCF生物化推板泵和一个Nimbus电动液压能量转换器组成。控制逻辑基于左主泵交替跳动方案。右心室末期射血和左心室末期充盈之间的时间差决定了执行器速度的调整。泵可自由充盈，因此左右血流差异很容易得到调节。一个原型系统已经建成并开始测试，以验证和完善设计细节。
