Saadh Mohamed J, Ehymayed Hadi Mohammed, Alazzawi Tuqa S, Fahdil Ali A, Athab Zainab H, Yarmukhamedov Bekhzod, Al-Anbari Hayder Hamid Abbas, Shallal Mohammed Mohsin, Alsaikhan Fahad, Farhood Bagher
Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
Department of Medical Laboratory Technics, Al-Noor University College, Nineveh, Iraq.
Cell Biochem Biophys. 2025 Mar;83(1):109-133. doi: 10.1007/s12013-024-01492-6. Epub 2024 Sep 7.
Despite multiple diagnostic and therapeutic advances, including surgery, radiation therapy, and chemotherapy, cancer preserved its spot as a global health concern. Prompt cancer diagnosis, treatment, and prognosis depend on the discovery of new biomarkers and therapeutic strategies. Circular RNAs (circRNAs) are considered as a stable, conserved, abundant, and varied group of RNA molecules that perform multiple roles such as gene regulation. There is evidence that circRNAs interact with RNA-binding proteins, especially capturing miRNAs. An extensive amount of research has presented the substantial contribution of circRNAs in various types of cancer. To fully understand the linkage between circRNAs and cancer growth as a consequence of various cell death processes, including autophagy, ferroptosis, and apoptosis, more research is necessary. The expression of circRNAs could be controlled to limit the occurrence and growth of cancer, providing a more encouraging method of cancer treatment. Consequently, it is critical to understand how circRNAs affect various forms of cancer cell death and evaluate whether circRNAs could be used as targets to induce tumor death and increase the efficacy of chemotherapy. The current study aims to review and comprehend the effects that circular RNAs exert on cell apoptosis, autophagy, and ferroptosis in cancer to investigate potential cancer treatment targets.
尽管在诊断和治疗方面取得了多项进展，包括手术、放射治疗和化疗，但癌症仍然是全球关注的健康问题。癌症的早期诊断、治疗和预后取决于新生物标志物和治疗策略的发现。环状RNA（circRNAs）被认为是一组稳定、保守、丰富且多样的RNA分子，它们发挥着多种作用，如基因调控。有证据表明，circRNAs与RNA结合蛋白相互作用，尤其是捕获微小RNA（miRNAs）。大量研究表明circRNAs在各种类型的癌症中发挥着重要作用。为了全面了解circRNAs与癌症生长之间因自噬、铁死亡和凋亡等各种细胞死亡过程而产生的联系，还需要更多的研究。可以控制circRNAs的表达以限制癌症的发生和发展，这为癌症治疗提供了一种更有前景的方法。因此，了解circRNAs如何影响各种形式的癌细胞死亡，并评估circRNAs是否可用作诱导肿瘤死亡和提高化疗疗效的靶点至关重要。本研究旨在综述和理解环状RNA对癌症细胞凋亡、自噬和铁死亡的影响，以探索潜在的癌症治疗靶点。
