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Synthesis of peptide bonds by proteinases. Addition of organic cosolvents shifts peptide bond equilibria toward synthesis.

作者信息

Homandberg G A, Mattis J A, Laskowski M

出版信息

Biochemistry. 1978 Nov 28;17(24):5220-7. doi: 10.1021/bi00617a023.

DOI:10.1021/bi00617a023
PMID:31906
Abstract
摘要

相似文献

1
Synthesis of peptide bonds by proteinases. Addition of organic cosolvents shifts peptide bond equilibria toward synthesis.
Biochemistry. 1978 Nov 28;17(24):5220-7. doi: 10.1021/bi00617a023.
2
Complex formation of guanidinated bovine trypsin inhibitor (Kunitz) with trypsin, chymotrypsin and trypsinogen as studied by the spin-label technique.用自旋标记技术研究胍基化牛胰蛋白酶抑制剂（库尼兹）与胰蛋白酶、胰凝乳蛋白酶和胰蛋白酶原的复合物形成。
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3
Thermodynamic stability effects of single peptide bond hydrolysis in protein inhibitors of serine proteinases.丝氨酸蛋白酶蛋白抑制剂中单个肽键水解的热力学稳定性影响
J Mol Biol. 1996 Mar 8;256(4):793-802. doi: 10.1006/jmbi.1996.0125.
4
Soybean trypsin inhibitor (Kunitz) is doubleheaded. Kinetics of the interaction of alpha-chymotrypsin with each side.大豆胰蛋白酶抑制剂（Kunitz）是双头的。α-胰凝乳蛋白酶与每一侧相互作用的动力学。
Biochim Biophys Acta. 1981 Jan 15;657(1):58-72. doi: 10.1016/0005-2744(81)90130-3.
5
Interaction of the Kunitz soybean trypsin inhibitor with bovine trypsin. Evidence for an an acy-enzyme intermediate during complexation.库尼茨大豆胰蛋白酶抑制剂与牛胰蛋白酶的相互作用。络合过程中酰基酶中间体的证据。
Biochemistry. 1977 May 31;16(11):2474-8. doi: 10.1021/bi00630a024.
6
Potato tuber protein proteinase inhibitors belonging to the Kunitz soybean inhibitor family.属于库尼茨大豆抑制剂家族的马铃薯块茎蛋白酶抑制剂。
Biochemistry (Mosc). 1997 Dec;62(12):1367-74.
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The primary structure of Vipera ammodytes venom trypsin inhibitor I.
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Effect of dietary raw soybean and soybean trypsin inhibitor on trypsin and chymotrypsin activities in the pancreas and in small intestinal juice of growing swine.日粮生大豆及大豆胰蛋白酶抑制剂对生长猪胰腺和小肠液中胰蛋白酶及糜蛋白酶活性的影响
J Nutr. 1977 Jan;107(1):156-65. doi: 10.1093/jn/107.1.156.
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Effect of feeding raw soybean flour on the digestion of the adult sheep.饲喂生大豆粉对成年绵羊消化的影响。
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Soybean proteinase inhibitors and human proteolytic enzymes: selective inactivation of inhibitors by treatment with human gastric juice.大豆蛋白酶抑制剂与人体蛋白水解酶：通过用人体胃液处理实现抑制剂的选择性失活
J Nutr. 1981 Dec;111(12):2045-51. doi: 10.1093/jn/111.12.2045.

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Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation.
酶原激活赋予关键肽键热力学稳定性，并保护人阳离子胰蛋白酶免受降解。
J Biol Chem. 2014 Feb 21;289(8):4753-61. doi: 10.1074/jbc.M113.538884. Epub 2014 Jan 8.
4
Use of enzymes in peptide synthesis.酶在肽合成中的应用。
Appl Biochem Biotechnol. 1982 Sep;7(5):385-99. doi: 10.1007/BF02798320.
5
Alteration of the disulfide-coupled folding pathway of BPTI by circular permutation.通过环形排列改变抑肽酶的二硫键偶联折叠途径。
Protein Sci. 2004 May;13(5):1182-96. doi: 10.1110/ps.03563704.
6
An enigmatic peptide ligation reaction: protease-catalyzed oligomerization of a native protein segment in neat aqueous solution.一种神秘的肽连接反应：蛋白酶催化的天然蛋白质片段在纯水溶液中的寡聚化。
Protein Sci. 2000 Apr;9(4):734-41. doi: 10.1110/ps.9.4.734.
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Breaking the low barrier hydrogen bond in a serine protease.打破丝氨酸蛋白酶中的低势垒氢键。
Protein Sci. 1999 Feb;8(2):410-7. doi: 10.1110/ps.8.2.410.
8
Conformationally driven protease-catalyzed splicing of peptide segments: V8 protease-mediated synthesis of fragments derived from thermolysin and ribonuclease A.构象驱动的蛋白酶催化肽段剪接：V8蛋白酶介导源自嗜热菌蛋白酶和核糖核酸酶A的片段合成
Protein Sci. 1997 Oct;6(10):2233-41. doi: 10.1002/pro.5560061018.
9
The curious case of protein splicing: mechanistic insights suggested by protein semisynthesis.蛋白质剪接的奇特案例：蛋白质半合成所揭示的机制见解
Protein Sci. 1993 May;2(5):697-705. doi: 10.1002/pro.5560020501.
10
Peptide segment ligation strategy without use of protecting groups.无需使用保护基团的肽段连接策略。
Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6584-8. doi: 10.1073/pnas.91.14.6584.