Department of Laboratory Medicine, Gyeongsang National University Hospital and Gyeongsang National University College of Medicine, Jinju, South Korea.
Institute of Health Science, Gyeongsang National University, Jinju, South Korea.
BMC Ophthalmol. 2020 Jan 6;20(1):6. doi: 10.1186/s12886-019-1293-9.
Serum 25-hydroxyvitamin D (25 (OH) D) levels are associated with various pathologic ocular conditions. Few studies have assessed 25 (OH) D concentrations in non-serum specimens, and none to date has assessed 25 (OH) D concentrations in human aqueous humor and their association with ocular diseases. This study investigated the possible correlations between 25 (OH) D concentrations in aqueous humor and serum and whether vitamin D concentrations in aqueous humor were associated with cataract.
This study prospectively enrolled 136 patients, including 87 with senile cataract and 49 with diabetic cataract, who underwent cataract surgery from January to November 2017. 25 (OH) D was measured in aqueous humor and serum specimens collected from all patients, and their correlation was analyzed statistically. Clinical and laboratory data, including the results of ophthalmologic examinations, were compared in the two groups of cataract patients.
No correlation was observed between 25 (OH) D concentrations in aqueous humor and serum (P = 0.381). 25 (OH) D concentrations in aqueous humor were significantly higher in patients with diabetic than senile cataract (P = 0.006). Multivariate logistic regression analysis showed that the adjusted odds ratio for diabetic cataract for the highest compared with the lowest quartile of 25 (OH) D concentration in aqueous humor was 4.36 ng/ml (95% confidence interval [CI]: 1.33-14.34 ng/ml; P = 0.015). Multivariate linear regression analysis showed that 25(OH) D concentration in aqueous humor was 2.68 ng/ml (95% CI: 0.34-5.01 ng/ml; P = 0.025) higher in patients with diabetic than senile cataract.
25(OH) D concentrations in aqueous humor and serum did not correlate with each other. Higher 25(OH) D level in aqueous humor was associated with diabetic cataract. These findings suggest that studies of vitamin D levels in patients with ocular conditions should include measurements of vitamin D levels in aqueous humor.
血清 25-羟维生素 D（25（OH）D）水平与各种眼部病理状况有关。很少有研究评估非血清标本中的 25（OH）D 浓度，迄今为止，也没有研究评估人眼房水中的 25（OH）D 浓度及其与眼部疾病的关系。本研究旨在探讨房水中 25（OH）D 浓度与血清之间的可能相关性，以及房水中维生素 D 浓度是否与白内障有关。
本研究前瞻性纳入了 2017 年 1 月至 11 月期间接受白内障手术的 136 例患者，其中 87 例为老年性白内障，49 例为糖尿病性白内障。对所有患者的房水和血清标本进行 25（OH）D 检测，并进行统计学分析。比较两组白内障患者的临床和实验室数据，包括眼科检查结果。
房水中 25（OH）D 浓度与血清之间无相关性（P=0.381）。糖尿病性白内障患者房水中 25（OH）D 浓度明显高于老年性白内障患者（P=0.006）。多变量 logistic 回归分析显示，与房水中 25（OH）D 浓度最低四分位数相比，最高四分位数的糖尿病性白内障的调整优势比为 4.36ng/ml（95%置信区间[CI]：1.33-14.34ng/ml；P=0.015）。多变量线性回归分析显示，糖尿病性白内障患者房水中 25（OH）D 浓度比老年性白内障患者高 2.68ng/ml（95%CI：0.34-5.01ng/ml；P=0.025）。
房水中和血清中的 25（OH）D 浓度彼此之间没有相关性。房水中 25（OH）D 水平升高与糖尿病性白内障有关。这些发现表明，对眼部疾病患者维生素 D 水平的研究应包括房水中维生素 D 水平的测量。
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