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本文引用的文献

1
Generation of diffuse intrinsic pontine glioma mouse models by brainstem-targeted in utero electroporation.通过针对脑干的子宫内电穿孔生成弥漫性内在脑桥神经胶质瘤小鼠模型。
Neuro Oncol. 2020 Mar 5;22(3):381-392. doi: 10.1093/neuonc/noz197.
2
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.H3K27M 诱导 PRC2 介导的抑制性 H3K27me2/me3 染色质扩散缺陷，并对神经胶质瘤发生至关重要。
Nat Commun. 2019 Mar 19;10(1):1262. doi: 10.1038/s41467-019-09140-x.
3
Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression.组蛋白 H3.3 K27M 加速自发性脑桥神经胶质瘤的发生，并驱动二价基因表达的受限变化。
Cancer Cell. 2019 Jan 14;35(1):140-155.e7. doi: 10.1016/j.ccell.2018.11.015. Epub 2018 Dec 27.
4
H3.3 Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.H3.3在小鼠胚胎神经祖细胞中与Trp53缺失和PDGFRA扩增协同作用，诱导侵袭性高级别胶质瘤。
Cancer Cell. 2017 Nov 13;32(5):684-700.e9. doi: 10.1016/j.ccell.2017.09.014. Epub 2017 Oct 26.
5
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.1000例儿童高级别和弥漫性脑桥内胶质瘤的综合分子荟萃分析
Cancer Cell. 2017 Oct 9;32(4):520-537.e5. doi: 10.1016/j.ccell.2017.08.017. Epub 2017 Sep 28.
6
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.EZH2 是 H3K27M 突变型小儿脑胶质瘤的潜在治疗靶点。
Nat Med. 2017 Apr;23(4):483-492. doi: 10.1038/nm.4293. Epub 2017 Feb 27.
7
Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma.弥漫性脑桥内生型胶质瘤中驱动基因突变的时空同质性
Nat Commun. 2016 Apr 6;7:11185. doi: 10.1038/ncomms11185.
8
Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics.弥漫性内在脑桥和中线高级别神经胶质瘤的空间基因组异质性：对诊断性活检和靶向治疗的影响。
Acta Neuropathol Commun. 2016 Jan 4;4:1. doi: 10.1186/s40478-015-0269-0.
9
Modeling Adult Gliomas Using RCAS/t-va Technology.利用 RCAS/t-va 技术建立成人脑胶质瘤模型。
Transl Oncol. 2009 May;2(2):89-95. doi: 10.1593/tlo.09100.
10
Pediatric brain stem gliomas: an update.小儿脑干胶质瘤：最新进展
Childs Nerv Syst. 1998 Apr-May;14(4-5):167-73. doi: 10.1007/s003810050205.

Modeling DIPG in the mouse brainstem.

作者信息

Siddaway Robert, Hawkins Cynthia

机构信息

Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

Division of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada.

出版信息

Neuro Oncol. 2020 Mar 5;22(3):307-308. doi: 10.1093/neuonc/noaa003.

DOI:10.1093/neuonc/noaa003
PMID:31907541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7058439/
Abstract
摘要