[与阿昔洛韦类似的化合物。I. 核苷“完整”类似物的合成]
[Compounds similar to acyclovir. I. Synthesis of "complete" analogs of nucleosides].
作者信息
Kochetkova S V, Tsilevich T L, Smirnov I P, Shchaveleva I L, Khorlin A A
出版信息
Bioorg Khim. 1988 Jun;14(6):820-3.
PMID:3190771
Abstract
"Full" acyclic analogues of ribonucleosides, 1-(1,2,6-trihydroxy-4-oxahex-3-yl)thymine and -cytosine, 3- and 9-(1,2,6-trihydroxy-4-oxahex-3-yl)adenine, and 9-(1,2,6-trihydroxy-4-oxahex-3-yl)guanine, have been prepared by condensation of silylated nucleo-bases with 1,4,5,6-tetraacetoxy-3-oxahexane in the presence of Lewis acids followed by deacetylation.
摘要
核糖核苷的“全”无环类似物，1-(1,2,6-三羟基-4-氧杂己-3-基)胸腺嘧啶和 -胞嘧啶、3-和9-(1,2,6-三羟基-4-氧杂己-3-基)腺嘌呤以及9-(1,2,6-三羟基-4-氧杂己-3-基)鸟嘌呤，已通过在路易斯酸存在下使硅烷化核苷碱与1,4,5,6-四乙酰氧基-3-氧杂己烷缩合，然后进行脱乙酰化反应制备而成。
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