Shchaveleva I L, Smirnov I P, Kochetkova S V, Tsilevich T L, Khorlin A A
Bioorg Khim. 1988 Jun;14(6):824-7.
Acyclic analogues of nucleosides, viz.9- and 3-(1,6-dihydroxy-4-oxahex-3-yl)adenine, 9-(1,6-dihydroxy-4-oxahex-3-yl)guanine, 1-(1,6-dihydroxy-4-oxahex-3-yl)cytosine and thymine, with C3'-C4' bond of the furanose ring cleaved, have been prepared by condensation of trimethylsilyl derivatives of nucleic acid bases with 1,4,6-triacetoxy-3-oxahexane in the presence of Lewis acids followed by treatment with metanolic ammonia.
核苷的无环类似物，即9 - 和3 -（1,6 - 二羟基 - 4 - 氧杂己 - 3 - 基）腺嘌呤、9 -（1,6 - 二羟基 - 4 - 氧杂己 - 3 - 基）鸟嘌呤、1 -（1,6 - 二羟基 - 4 - 氧杂己 - 3 - 基）胞嘧啶和胸腺嘧啶，其呋喃糖环的C3'-C4'键已断裂，通过在路易斯酸存在下核酸碱基的三甲基硅烷基衍生物与1,4,6 - 三乙酰氧基 - 3 - 氧杂己烷缩合，然后用甲醇氨处理来制备。
