Division of Hematology/Oncology, Department of Internal Medicine, Kosin University College of Medicine, Kosin University Gospel Hospital, 262 Gamcheon-ro, Seo-gu, Busan, 49267, South Korea.
Department of Biochemistry Cancer Research Institute, Kosin University College of Medicine, Busan, South Korea.
Int J Hematol. 2020 Apr;111(4):559-566. doi: 10.1007/s12185-019-02816-6. Epub 2020 Jan 6.
The International Prognostic Index (IPI) and other prognostic models cannot accurately classify risks in patients with lower-risk diffuse large B cell lymphoma (DLBCL). This study retrospectively analyzed serum levels of ferritin (500 and ≥ 500 ng/mL) and other reported risk factors for survival in 312 patients. High and high-intermediate risk IPI scores (hazard ratio (HR) [95% confidence interval (CI)] 2.22 [1.33, 3.72], P = 0.002 and 2.29 [1.33, 3.93], P = 0.003, respectively) and ferritin concentration ≥ 500 ng/mL (HR [95% CI] 2.22 [1.37, 3.60], P = 0.001 and 2.18 [1.31, 3.63], P = 0.003, respectively) were independent poor prognostic factors for 5-year progression-free survival (PFS) and overall survival (OS) rates in all patients. Additionally, high ferritin level (≥ 500 ng/mL) was an independent poor prognostic factor for PFS and OS in patients with lower-risk IPI (HR [95% CI] 3.37 [1.36, 8.33], P = 0.009 and 3.29 [1.23, 8.83], P = 0.0018, respectively). In conclusion, serum ferritin levels may be helpful in predicting survival in patients with DLBCL, especially in those with lower-risk IPI scores.
国际预后指数（IPI）和其他预后模型无法准确地对低危弥漫性大 B 细胞淋巴瘤（DLBCL）患者的风险进行分类。本研究回顾性分析了 312 例患者的血清铁蛋白水平（500 及 ≥500ng/mL）和其他报告的生存风险因素。高和高中危 IPI 评分（危险比[95%置信区间（CI）] 2.22[1.33, 3.72]，P=0.002 和 2.29[1.33, 3.93]，P=0.003）和铁蛋白浓度≥500ng/mL（危险比[95%CI] 2.22[1.37, 3.60]，P=0.001 和 2.18[1.31, 3.63]，P=0.003）是所有患者 5 年无进展生存（PFS）和总生存（OS）率的独立不良预后因素。此外，高铁蛋白水平（≥500ng/mL）是低危 IPI 患者 PFS 和 OS 的独立不良预后因素（危险比[95%CI] 3.37[1.36, 8.33]，P=0.009 和 3.29[1.23, 8.83]，P=0.0018）。总之，血清铁蛋白水平可能有助于预测 DLBCL 患者的生存情况，尤其是低危 IPI 评分的患者。
