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Examination of subchondral bone architecture in experimental osteoarthritis by microscopic computed axial tomography.

作者信息

Layton M W, Goldstein S A, Goulet R W, Feldkamp L A, Kubinski D J, Bole G G

机构信息

Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0486.

出版信息

Arthritis Rheum. 1988 Nov;31(11):1400-5. doi: 10.1002/art.1780311109.

DOI:10.1002/art.1780311109
PMID:3190784
Abstract

Subchondral bone changes have been proposed as an early event in the pathogenesis of osteoarthritis. In this study, microscopic computed axial tomography was used to evaluate the subchondral bone structure in femoral heads from a guinea pig model of osteoarthritis. Examination of trabecular bone within the femoral head showed a highly significant increase in bone fraction in the experimental animals. This was due to the development of trabeculae that were thicker and closer together. We conclude that trabecular remodeling may be an early event in this model of osteoarthritis.

摘要

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