Flash Moses J E, Garland Wendy H, Martey Emily B, Schackman Bruce R, Oksuzyan Sona, Scott Justine A, Jeng Philip J, Rubio Marisol, Losina Elena, Freedberg Kenneth A, Kulkarni Sonali P, Hyle Emily P
Divisions of General Internal Medicine and Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Medical Practice Evaluation Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Open Forum Infect Dis. 2019 Dec 16;6(12):ofz537. doi: 10.1093/ofid/ofz537. eCollection 2019 Dec.
The Los Angeles County (LAC) Division of HIV and STD Programs implemented a medical care coordination (MCC) program to address the medical and psychosocial service needs of people with HIV (PWH) at risk for poor health outcomes.
Our objective was to evaluate the impact and cost-effectiveness of the MCC program. Using the CEPAC-US model populated with clinical characteristics and costs observed from the MCC program, we projected lifetime clinical and economic outcomes for a cohort of high-risk PWH under 2 strategies: (1) No MCC and (2) a 2-year MCC program. The cohort was stratified by acuity using social and clinical characteristics. Baseline viral suppression was 33% in both strategies; 2-year suppression was 33% with No MCC and 57% with MCC. The program cost $2700/person/year. Model outcomes included quality-adjusted life expectancy, lifetime medical costs, and cost-effectiveness. The cost-effectiveness threshold for the incremental cost-effectiveness ratio (ICER) was $100 000/quality-adjusted life-year (QALY).
With MCC, life expectancy increased from 10.07 to 10.94 QALYs, and costs increased from $311 300 to $335 100 compared with No MCC (ICER, $27 400/QALY). ICERs for high/severe, moderate, and low acuity were $30 500/QALY, $25 200/QALY, and $77 400/QALY. In sensitivity analysis, MCC remained cost-effective if 2-year viral suppression was ≥39% even if MCC costs increased 3-fold.
The LAC MCC program improved survival and was cost-effective. Similar programs should be considered in other settings to improve outcomes for high-risk PWH.
洛杉矶县(LAC)的艾滋病毒和性传播疾病项目部门实施了一项医疗护理协调(MCC)计划,以满足健康状况不佳风险较高的艾滋病毒感染者(PWH)的医疗和心理社会服务需求。
我们的目标是评估MCC计划的影响和成本效益。使用CEPAC-US模型,该模型包含从MCC计划中观察到的临床特征和成本,我们预测了高危PWH队列在两种策略下的终身临床和经济结果:(1)无MCC和(2)为期两年的MCC计划。根据社会和临床特征按病情严重程度对队列进行分层。两种策略的基线病毒抑制率均为33%;无MCC时2年抑制率为33%,MCC时为57%。该计划的成本为每人每年2700美元。模型结果包括质量调整生命预期、终身医疗成本和成本效益。增量成本效益比(ICER)的成本效益阈值为100000美元/质量调整生命年(QALY)。
与无MCC相比,MCC使预期寿命从10.07个QALY增加到10.94个QALY,成本从311300美元增加到335100美元(ICER,27400美元/QALY)。高/重度、中度和轻度病情的ICER分别为30500美元/QALY、25200美元/QALY和77400美元/QALY。在敏感性分析中,即使MCC成本增加三倍,若2年病毒抑制率≥39%,MCC仍具有成本效益。
LAC的MCC计划提高了生存率且具有成本效益。其他地区应考虑实施类似计划,以改善高危PWH的治疗效果。