Department of Management Science and Engineering, Stanford University, Stanford, California, United States of America.
PLoS Med. 2020 Oct 13;17(10):e1003239. doi: 10.1371/journal.pmed.1003239. eCollection 2020 Oct.
Cycles of incarceration, drug abuse, and poverty undermine ongoing public health efforts to reduce overdose deaths and the spread of infectious disease in vulnerable populations. Jail diversion programs aim to divert low-level drug offenders toward community care resources, avoiding criminal justice costs and disruptions in treatment for HIV, hepatitis C virus (HCV), and drug abuse. We sought to assess the health benefits and cost-effectiveness of a jail diversion program for low-level drug offenders.
We developed a microsimulation model, calibrated to King County, Washington, that captured the spread of HIV and HCV infections and incarceration and treatment systems as well as preexisting interventions such as needle and syringe programs and opiate agonist therapy. We considered an adult population of people who inject drugs (PWID), people who use drugs but do not inject (PWUD), men who have sex with men, and lower-risk heterosexuals. We projected discounted lifetime costs and quality-adjusted life years (QALYs) over a 10-year time horizon with and without a jail diversion program and calculated resulting incremental cost-effectiveness ratios (ICERs) from the health system and societal perspectives. We also tracked HIV and HCV infections, overdose deaths, and jail population size. Over 10 years, the program was estimated to reduce HIV and HCV incidence by 3.4% (95% CI 2.7%-4.0%) and 3.3% (95% CI 3.1%-3.4%), respectively, overdose deaths among PWID by 10.0% (95% CI 9.8%-10.8%), and jail population size by 6.3% (95% CI 5.9%-6.7%). When considering healthcare costs only, the program cost $25,500/QALY gained (95% CI $12,600-$48,600). Including savings from reduced incarceration (societal perspective) improved the ICER to $6,200/QALY gained (95% CI, cost-saving $24,300). Sensitivity analysis indicated that cost-effectiveness depends on diversion program participants accessing community programs such as needle and syringe programs, treatment for substance use disorder, and HIV and HCV treatment, as well as diversion program cost. A limitation of the analysis is data availability, as fewer data are available for diversion programs than for more established interventions aimed at people with substance use disorder. Additionally, like any model of a complex system, our model relies on simplifying assumptions: For example, we simplified pathways in the healthcare and criminal justice systems, modeled an average efficacy for substance use disorder treatment, and did not include costs associated with homelessness, unemployment, and breakdown in family structure.
We found that diversion programs for low-level drug offenders are likely to be cost-effective, generating savings in the criminal justice system while only moderately increasing healthcare costs. Such programs can reduce incarceration and its associated costs, and also avert overdose deaths and improve quality of life for PWID, PWUD, and the broader population (through reduced HIV and HCV transmission).
监禁、药物滥用和贫困的循环破坏了减少过量死亡和在弱势群体中传播传染病的公共卫生工作。监狱转移计划旨在将低级吸毒者转移到社区护理资源,避免刑事司法成本和治疗艾滋病毒、丙型肝炎病毒 (HCV) 和药物滥用的中断。我们旨在评估针对低级吸毒者的监狱转移计划的健康益处和成本效益。
我们开发了一个微观模拟模型,根据华盛顿金县进行了校准,该模型捕获了艾滋病毒和 HCV 感染以及监禁和治疗系统的传播,以及现有的干预措施,如针具和注射器计划和阿片类激动剂治疗。我们考虑了一个使用毒品的成年人(PWID)、不使用毒品的人(PWUD)、男男性行为者和低风险异性恋者的人群。我们预测了 10 年内有和没有监狱转移计划的贴现终生成本和质量调整生命年 (QALY),并从卫生系统和社会角度计算了由此产生的增量成本效益比 (ICER)。我们还跟踪了 HIV 和 HCV 感染、过量死亡和监狱人口规模。在 10 年内,该计划预计将分别减少 3.4%(95%CI 2.7%-4.0%)和 3.3%(95%CI 3.1%-3.4%)的 HIV 和 HCV 发病率、PWID 中的过量死亡人数减少 10.0%(95%CI 9.8%-10.8%),以及监狱人口减少 6.3%(95%CI 5.9%-6.7%)。仅考虑医疗保健成本,该计划的成本为 25500 美元/QALY(95%CI 12600 美元至 48600 美元)。包括减少监禁所节省的费用(社会视角)将 ICER 提高到 6200 美元/QALY(95%CI,节省 24300 美元)。敏感性分析表明,成本效益取决于转移计划参与者是否能够获得社区计划,如针具和注射器计划、药物使用障碍治疗以及艾滋病毒和 HCV 治疗,以及转移计划的成本。分析的一个限制是数据可用性,因为转移计划的数据比针对药物使用障碍的更成熟的干预措施的数据要少。此外,像任何复杂系统的模型一样,我们的模型依赖于简化假设:例如,我们简化了医疗保健和刑事司法系统中的途径,为药物使用障碍治疗建模平均疗效,并且不包括与无家可归、失业和家庭结构破裂相关的成本。
我们发现,针对低级吸毒者的转移计划可能具有成本效益,在刑事司法系统中节省成本,同时仅适度增加医疗保健成本。这些计划可以减少监禁和相关成本,还可以避免过量死亡并改善 PWID、PWUD 和更广泛人群的生活质量(通过减少 HIV 和 HCV 的传播)。