Bukeĭ T I, Filippov A K, Vasilets L A, Porotikov V I
Biull Eksp Biol Med. 1988 Oct;106(10):456-8.
The action of the anthracycline antibiotics rubomycin and its nitroxyl analogue ehoxyl(ruboxyl) at the concentration 100 mg/l was studied in the experiments, have been carried out with the isolated bundles of frog atrium using simultaneous registration of the ionic currents (or the active potentials) and the contraction. It has been shown, that rubomycin caused an action of potential shortening, membrane depolarization, increasing of the background outward current IKI, slowing of the muscle relaxation and the growth of the ionic contraction, associated with the Na/Ca exchange. Nitroxyl derivative of the rubomycin ruboxyl, exhibited small toxicity, did not change the ionic currents and the parameters of the mechanical activity. It is assumed, that cardiotoxicity of anthracyclines is in the great degree due to their ability to block the elimination of the Ca++ from the cell via the Na/Ca exchange, that results in the disturbance of the Ca-homeostasis of the cardiomyocyte and its calcium overload.
在实验中，研究了浓度为100mg/l的蒽环类抗生素柔红霉素及其硝酰类似物依索昔芬（柔红霉素肟）的作用，实验是使用蛙心房离体肌束同时记录离子电流（或动作电位）和收缩进行的。结果表明，柔红霉素引起动作电位缩短、膜去极化、背景外向电流IKI增加、肌肉松弛减慢以及与钠/钙交换相关的离子收缩增强。柔红霉素的硝酰衍生物柔红霉素肟毒性较小，不改变离子电流和机械活动参数。据推测，蒽环类药物的心脏毒性在很大程度上是由于它们能够通过钠/钙交换阻断钙离子从细胞内的清除，这导致心肌细胞钙稳态紊乱及其钙超载。
