Vasilets L A, Ganieva L Kh
Biull Eksp Biol Med. 1987 Aug;104(8):233-5.
It has been shown that 2 months after discontinuation of rubomycin administration to rats at a dose of 0.7 mg/kg there is a considerable damage of cardiomyocyte morphology manifested in myofibril disintegration and contractions, vacuolization, as well as chromatin coagulation indicative of the inhibition of nuclear synthesis. The experiments on the papillary muscles isolated from the same hearts have demonstrated a depression of Na-conductivity and reduction in the force of isometric contractions. Ruboxyl at a dose of 3 mg/kg caused no changes in the morphology and electrical activity. It is suggested that depression of Na-conductivity is mediated by a decrease in the number of sarcolemmal channels due to the inhibition of the channel-forming protein synthesis.
研究表明，以0.7mg/kg的剂量给大鼠停用柔红霉素2个月后，心肌细胞形态出现相当大的损伤，表现为肌原纤维解体和收缩、空泡化以及染色质凝聚，这表明核合成受到抑制。对从同一心脏分离出的乳头肌进行的实验表明，钠电导率降低，等长收缩力减小。3mg/kg剂量的鲁博昔尔未引起形态和电活动的变化。有人认为，钠电导率降低是由于通道形成蛋白合成受到抑制，导致肌膜通道数量减少所致。
