新生儿血斑的代谢组学和加合物组学可用于回顾性评估生命早期暴露组。
Metabolomics and adductomics of newborn bloodspots to retrospectively assess the early-life exposome.
机构信息
Department of Environmental Medicine and Public Health.
The Institute for Exposomics Research, Icahn School of Medicine at Mount Sinai, New York, New York.
出版信息
Curr Opin Pediatr. 2020 Apr;32(2):300-307. doi: 10.1097/MOP.0000000000000875.
PURPOSE OF REVIEW
Exposomics studies can measure health-relevant chemical exposures during a lifetime and estimate the 'internal' environment. However, sampling limitations make these features difficult to capture directly during the critical neonatal time period.
RECENT FINDINGS
We review the use of newborn dried bloodspots (DBS) archived from newborn screening programs for exposomic analysis in epidemiological children's health studies. Emerging 'omics technologies such as adductomics and metabolomics have been adapted for DBS analysis, and these technologies can now provide valuable etiological information on the complex interplay between exposures, biological response, and population phenotypes.
SUMMARY
Adductomics and metabolomics of DBS can provide robust measurements for retrospective epidemiological investigations. With extensive bioarchiving programs in the United States and other countries, DBS are poised to substantially aid epidemiological studies, particularly for rare and low-frequency childhood diseases and disorders.
目的综述
暴露组学研究可以测量一生中与健康相关的化学暴露，并估计“内部”环境。然而，采样限制使得这些特征难以在关键的新生儿时期直接捕捉。
最近的发现
我们回顾了利用新生儿筛查计划中存档的新生儿干血斑（DBS）进行暴露组学分析在流行病学儿童健康研究中的应用。新兴的“组学”技术，如加合物组学和代谢组学，已经被应用于 DBS 分析，这些技术现在可以为暴露、生物反应和人群表型之间的复杂相互作用提供有价值的病因学信息。
总结
DBS 的加合物组学和代谢组学可以为回顾性流行病学研究提供可靠的测量结果。随着美国和其他国家广泛的生物存档计划，DBS 有望极大地帮助流行病学研究，特别是对于罕见和低频率的儿童疾病和障碍。
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