• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

METTL4 is an snRNA mAm methyltransferase that regulates RNA splicing.

作者信息

Chen Hao, Gu Lei, Orellana Esteban A, Wang Yuanyuan, Guo Jiaojiao, Liu Qi, Wang Longfei, Shen Zhangfei, Wu Hao, Gregory Richard I, Xing Yi, Shi Yang

机构信息

Division of Newborn Medicine and Program in Epigenetics, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.

出版信息

Cell Res. 2020 Jun;30(6):544-547. doi: 10.1038/s41422-019-0270-4. Epub 2020 Jan 8.

DOI:10.1038/s41422-019-0270-4
PMID:31913360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7264358/
Abstract
摘要

相似文献

1
METTL4 is an snRNA mAm methyltransferase that regulates RNA splicing.METTL4是一种调节RNA剪接的小核仁RNA(snRNA)甲基转移酶。
Cell Res. 2020 Jun;30(6):544-547. doi: 10.1038/s41422-019-0270-4. Epub 2020 Jan 8.
2
The U6 snRNA mA Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.U6 小核仁核糖核酸 mA 甲基转移酶 METTL16 调节 S-腺苷甲硫氨酸合成酶内含子保留。
Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003.
3
A comparative study of the biochemical properties of human and mouse recombinant O6-methylguanine-DNA methyltransferases.人和小鼠重组O6-甲基鸟嘌呤-DNA甲基转移酶生化特性的比较研究
Carcinogenesis. 1995 Feb;16(2):405-11. doi: 10.1093/carcin/16.2.405.
4
METTL16, Methyltransferase-Like Protein 16: Current Insights into Structure and Function.METTL16,甲基转移酶样蛋白 16:结构与功能的最新研究进展。
Int J Mol Sci. 2021 Feb 22;22(4):2176. doi: 10.3390/ijms22042176.
5
Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1.小核仁RNA(snRNA)和小核仁RNA甲基转移酶Tgs1对酵母端粒酶RNA的超甲基化作用
J Cell Sci. 2008 Nov 1;121(Pt 21):3553-60. doi: 10.1242/jcs.033308. Epub 2008 Oct 7.
6
Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus.酵母小核RNA(snRNA)和小核仁RNA(snoRNA)帽结构的超甲基化需要一种定位于核仁的保守甲基转移酶。
Mol Cell. 2002 Apr;9(4):891-901. doi: 10.1016/s1097-2765(02)00484-7.
7
Cap-specific, terminal N-methylation by a mammalian mAm methyltransferase.由哺乳动物的mAm甲基转移酶进行的帽特异性末端N-甲基化。
Cell Res. 2019 Jan;29(1):80-82. doi: 10.1038/s41422-018-0117-4. Epub 2018 Nov 28.
8
The TbMTr1 spliced leader RNA cap 1 2'-O-ribose methyltransferase from Trypanosoma brucei acts with substrate specificity.来自布氏锥虫的TbMTr1剪接前导RNA帽1 2'-O-核糖甲基转移酶具有底物特异性。
J Biol Chem. 2008 Feb 8;283(6):3161-3172. doi: 10.1074/jbc.M707367200. Epub 2007 Nov 29.
9
Successful expression and purification of human CIAPIN1 in baculovirus-insect cell system and application of this system to investigation of its potential methyltransferase activity.人CIAPIN1在杆状病毒-昆虫细胞系统中的成功表达与纯化及其在研究其潜在甲基转移酶活性中的应用。
Int J Biol Macromol. 2008 Jan 1;42(1):27-32. doi: 10.1016/j.ijbiomac.2007.08.009. Epub 2007 Sep 8.
10
Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1).RNA帽鸟嘌呤-N2甲基转移酶(Tgs1)的特异性及作用机制
J Biol Chem. 2005 Feb 11;280(6):4021-4. doi: 10.1074/jbc.C400554200. Epub 2004 Dec 7.

引用本文的文献

1
A Genome-Wide Association Study of Anti-Müllerian Hormone (AMH) Levels in Samoan Women.萨摩亚女性抗苗勒管激素(AMH)水平的全基因组关联研究。
Genes (Basel). 2025 Jun 30;16(7):793. doi: 10.3390/genes16070793.
2
The crosstalk of mA-modified RNA with DNA damage repair.N6-甲基腺嘌呤修饰的RNA与DNA损伤修复的相互作用
Trends Biochem Sci. 2025 Jul 21. doi: 10.1016/j.tibs.2025.06.012.
3
RNA demethylase FTO uses conserved aromatic residues to recognize the mRNA 5' cap and promote efficient mA demethylation.RNA去甲基化酶FTO利用保守的芳香族残基识别mRNA 5'帽并促进高效的m⁶A去甲基化。
bioRxiv. 2025 May 10:2025.05.09.653100. doi: 10.1101/2025.05.09.653100.
4
Biological roles of enhancer RNA m6A modification and its implications in cancer.增强子RNA的m6A修饰的生物学作用及其在癌症中的意义。
Cell Commun Signal. 2025 May 30;23(1):254. doi: 10.1186/s12964-025-02254-4.
5
Homocysteine induced N-methyldeoxyadenosine modification perturbation elicits mitochondria dysfunction contributes to the impairment of learning and memory ability caused by early life stress in rats.同型半胱氨酸诱导的N-甲基脱氧腺苷修饰紊乱引发线粒体功能障碍,导致大鼠早期生活应激引起的学习和记忆能力损害。
Redox Biol. 2025 Jul;84:103668. doi: 10.1016/j.redox.2025.103668. Epub 2025 May 9.
6
Correlation of METTL4 genetic variants and severe pneumonia pediatric patients in Southern China.中国南方地区METTL4基因变异与重症肺炎患儿的相关性研究
BMC Genom Data. 2025 May 1;26(1):33. doi: 10.1186/s12863-025-01306-5.
7
The role of N(6)-methyladenosine (m6a) modification in cancer: recent advances and future directions.N⁶-甲基腺苷(m⁶A)修饰在癌症中的作用:最新进展与未来方向
EXCLI J. 2025 Jan 15;24:113-150. doi: 10.17179/excli2024-7935. eCollection 2025.
8
The interplay between RNA m6A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review.RNA m6A修饰与癌组织和非癌组织放射生物学之间的相互作用:一篇综述
Cancer Biol Med. 2025 Jan 17;21(12):1120-40. doi: 10.20892/j.issn.2095-3941.2024.0415.
9
The pseudorabies virus UL13 protein kinase triggers phosphorylation of the RNA demethylase FTO, which is associated with FTO-dependent suppression of interferon-stimulated gene expression.伪狂犬病病毒UL13蛋白激酶触发RNA去甲基化酶FTO的磷酸化,这与FTO依赖的干扰素刺激基因表达抑制相关。
J Virol. 2025 Feb 25;99(2):e0201924. doi: 10.1128/jvi.02019-24. Epub 2025 Jan 10.
10
Epigenetic Mechanisms in Osteoporosis: Exploring the Power of mA RNA Modification.骨质疏松症中的表观遗传机制:探索m⁶A RNA修饰的作用
J Cell Mol Med. 2025 Jan;29(1):e70344. doi: 10.1111/jcmm.70344.