Xie Xiaozhou, Fang Zhen, Zhang Haoyu, Wang Zheng, Li Jie, Jia Yuchen, Shang Liang, Cao Feng, Li Fei
Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
EXCLI J. 2025 Jan 15;24:113-150. doi: 10.17179/excli2024-7935. eCollection 2025.
N(6)-methyladenosine (m6A) modification is the most abundant and prevalent internal modification in eukaryotic mRNAs. The role of m6A modification in cancer has become a hot research topic in recent years and has been widely explored. m6A modifications have been shown to regulate cancer occurrence and progression by modulating different target molecules. This paper reviews the recent research progress of m6A modifications in cancer and provides an outlook on future research directions, especially the development of molecularly targeted drugs. See also the graphical abstract(Fig. 1).
N⁶-甲基腺苷（m⁶A）修饰是真核生物mRNA中最丰富且普遍存在的内部修饰。近年来，m⁶A修饰在癌症中的作用已成为热门研究课题，并得到了广泛探索。m⁶A修饰已被证明可通过调节不同的靶分子来调控癌症的发生和发展。本文综述了m⁶A修饰在癌症方面的最新研究进展，并对未来的研究方向，尤其是分子靶向药物的开发进行了展望。另见图1的图形摘要。
